cover of episode Why one in ten children have a food allergy | Dr. Gideon Lack

Why one in ten children have a food allergy | Dr. Gideon Lack

2024/8/15
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Gideon Lack
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主持著名true crime播客《Crime Junkie》的播音员和创始人。
Topics
Gideon Lack: 本期节目讨论了食物过敏的流行病学、病因及预防。食物过敏正在上升,已成为流行病。过敏反应是免疫系统对无害蛋白质的过度反应,这可能是由于免疫系统未能区分“好蛋白”和“坏蛋白”。通过皮肤接触的食物更容易引起过敏反应,而通过口腔接触的食物则更容易产生耐受性。LEAP研究表明,尽早、频繁地接触花生可以显著降低婴儿患花生过敏的风险。建议孕期母亲保持正常的饮食,婴儿出生后应尽早、频繁地接触各种食物,以降低过敏风险。肠道菌群和皮肤屏障在过敏反应中起着重要作用。母乳喂养对过敏症风险的影响尚不明确。目前有很多方法可以治疗食物过敏,例如脱敏疗法和单克隆抗体疗法。 Jonathan: 本期节目与Gideon Lack教授一起探讨了儿童食物过敏问题。节目中,我们了解到食物过敏的流行病学数据,过敏反应的免疫学机制,以及预防和治疗食物过敏的策略。Gideon Lack教授分享了他关于花生过敏研究的经验,以及这项研究如何改变了全球的过敏症指导方针。我们还讨论了肠道菌群、皮肤屏障以及其他环境因素在过敏反应中的作用。此外,我们还探讨了在日常生活中如何平衡过敏风险与益处,例如在学校和飞机上是否应该禁止坚果。

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The podcast discusses the rise in allergies, particularly in children, and introduces Professor Gideon Lack, who has researched and influenced allergy prevention guidelines.

Shownotes Transcript

Allergies are on the rise in both infants and adults. Many are calling it an epidemic. Allergies can limit your diet, cause irritation, and in some cases be life threatening. 

In today’s episode, we discuss the evidence suggesting that our gut plays a key role in protecting us from food allergies.

Professor Gideon Lack tells us how we can reduce the risk of allergies developing in children. Gideon also shares innovative ways to treat allergies and significantly reduce the risk of death. 

Gideon is Professor of Paediatric Allergy at King’s College London. His groundbreaking studies into allergies have reversed the official medical advice of multiple countries. 

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Timecodes

00:00 Allergies are on the rise

01:30 Quickfire questions

05:02 Allergies vs intolerances

06:48 Do allergies only develop in childhood?

11:18 Why allergic reactions happen

15:33 Hay fever and asthma 

18:28 How to spot birch pollen allergy

19:58 Which allergies do children develop?

26:50 Gideon’s light bulb moment

32:16 Does eczema play a role?

36:36 The importance of the gut microbiome

45:08 How to protect your baby

50:05 Skin and allergies

54:06 Should nuts be banned on planes?

57:49 The truth about airborne allergens

Books by our ZOE Scientists:

**Studies related to today’s episode: **

- Self-Reported Prevalence of Allergies in the USA and Impact on Skin—An Epidemiological Study on a Representative Sample of American Adults,) published in *International Journal of Environmental Research and Public Health *

- Trends in Allergic Conditions Among Children: United States, 1997–2011), published by *US National Center for Health Statistics *

- Early exposure hypothesis: where are we now?) published in Clinical and Translational Allergy 

- Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy), published in *New England Journal of Medicine *

- Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants), published in *New England Journal of Medicine *

- Birch Pollen Immunotherapy by Consumption of Apples), published by *AppleCare Project, Interreg Italy Austria *

- Food allergy and the gut), published in *Nature Reviews Gastroenterology & Hepatology *

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Episode transcripts are available here)