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#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.
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2022/4/25
The Peter Attia Drive
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What can genetic studies of centenarians and twins reveal about longevity?
Which genes with protective variants contribute to longevity?
How does the relationship between growth hormone and IGF-1 impact longevity?
Is growth hormone a viable longevity tool?
What role do longevity genotypes like APOE e2, Lp(a), Klotho, and CETP play?
Does a high TSH correlate with longevity?
What are the important pathways for longevity?
What insights can we gain from centenarian studies about nature vs. nurture?
How does the contraction of morbidity relate to improved healthspan?
How do you define healthspan?
What unique perspectives and positive attitudes do centenarians have?
What lessons can we learn from centenarians?
What is the history and potential of metformin for geroprotection?
What is the TAME trial and its significance for aging research?
What challenges are associated with studying metformin in animal models?
How could data from the TAME trial inform biomarkers of aging and proteomics studies?
What biomarkers are being sought to identify potential metformin beneficiaries?
How does metformin impact exercise, and what is the right indication for its use?
Are NAD precursors geroprotective?
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