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#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

2021/9/13

The Peter Attia Drive

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#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

The Peter Attia Drive

Chapters

What are the various definitions of aging?

How does disease relate to the biology of aging?

Can targeting diseases extend lifespan more than targeting biological aging?

Rapamycin as a longevity agent: What are the challenges?

Human studies using rapalogs for enhanced immune function

What role does inflammation play in aging-related functional declines and diseases?

Do rapalogs improve the immune response to a vaccine?

What are the roadblocks to studying gero-protective molecules in humans?

Potential benefits of rapamycin for age-related diseases: Periodontal, reproductive function, and more

What is the ideal length and frequency of rapamycin treatment for various indications like inflammation and longevity?

Biomarkers of aging and epigenetic clocks

Could a test calculate biological age?

The Dog Aging Project testing rapamycin in pet dogs

The role of the mTOR complexes

mTor inhibitor called Torin2, mitochondrial disease and other potential pathways

Catalytic inhibitors, sirtuins, and NAD

NAD precursors: help or hype?

Shownotes Transcript

#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process 02:40:39 Share

The Peter Attia Drive

Chapters

What are the various definitions of aging?

How does disease relate to the biology of aging?

Can targeting diseases extend lifespan more than targeting biological aging?

Rapamycin as a longevity agent: What are the challenges?

Human studies using rapalogs for enhanced immune function

What role does inflammation play in aging-related functional declines and diseases?

Do rapalogs improve the immune response to a vaccine?

What are the roadblocks to studying gero-protective molecules in humans?

Potential benefits of rapamycin for age-related diseases: Periodontal, reproductive function, and more

What is the ideal length and frequency of rapamycin treatment for various indications like inflammation and longevity?

Biomarkers of aging and epigenetic clocks

Could a test calculate biological age?

The Dog Aging Project testing rapamycin in pet dogs

The role of the mTOR complexes

mTor inhibitor called Torin2, mitochondrial disease and other potential pathways

Catalytic inhibitors, sirtuins, and NAD

NAD precursors: help or hype?

Shownotes Transcript

#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process