A hangover is a combination of psychological and physiological symptoms experienced after drinking, when blood alcohol concentration is close to or has returned to zero. Symptoms include headache, nausea, vomiting, low mood, anxiety, and impaired decision-making.
Alcohol is converted into acetaldehyde, a toxic chemical that causes nausea and sickness. It also leads to changes in blood sugar, inflammation in the stomach and small intestine, and affects neurotransmitters like GABA, dopamine, and serotonin, which can cause low mood and anxiety.
Hangover research is challenging because it's difficult to measure hangover symptoms accurately, as people must have no alcohol left in their system. Additionally, people are reluctant to participate in hangover studies, and hangovers are often seen as trivial, receiving less attention than other alcohol-related research.
Miracle and SureShot are probiotics that claim to reduce alcohol absorption and support alcohol metabolism. Miracle contains Bacillus coagulans and L-cysteine, while SureShot claims to break down alcohol into water and carbon dioxide and replenish electrolytes.
The evidence for these products is limited. Studies are often based on animal models or small human trials, and they focus on changes in alcohol absorption rather than observable effects on hangover symptoms. These products, marketed as nutritional supplements, do not undergo the same rigorous testing as medications.
Effective methods to reduce hangover symptoms include rehydrating with water and electrolyte solutions, eating fatty foods before drinking to slow alcohol absorption, and taking B vitamins. However, there is no single miracle cure that can target all aspects of a hangover.
What if you could take a pill or a shot that could reduce your blood alcohol level and make you feel better in the morning? That’s the promise of a range of wellness products aiming to be the next big hangover antidote. But what exactly are hangovers, and which methods of preventing them are backed by science? Madeleine Finlay speaks to Dr Sally Adams, an alcohol researcher and associate professor of psychology at the University of Birmingham. Help support our independent journalism at theguardian.com/sciencepod)