Behaviors such as sloth and gluttony often have underlying neurological or medical causes. For example, sloth can be linked to sickness behaviors orchestrated by neurons that detect inflammation, while gluttony is influenced by the hypothalamus, which regulates appetite through hormones like leptin. These behaviors are not merely moral failings but are deeply rooted in brain function.
Fatigue and physical tiredness are primarily mediated by the brain, not the muscles. Signals from the motor parts of the brain to sensory areas create the perception of fatigue. Studies show that blocking these signals with magnetic pulses can reduce fatigue, indicating that the brain plays a central role in regulating physical exhaustion.
Leptin, a hormone produced by fat cells, signals to the hypothalamus about the body's fat stores. Low leptin levels trigger hunger, while high levels suppress appetite. In humans and animals like grizzly bears, leptin levels can change seasonally or due to genetic mutations, significantly impacting appetite and weight regulation.
Obesity can spread through social networks, similar to a communicable disease. Studies show that individuals are more likely to gain weight if their friends or social peers are obese, regardless of household factors. This suggests that social influence plays a significant role in eating behaviors and weight gain.
Benign envy is a positive emotion where one admires another's success and uses it as motivation. Malicious envy, on the other hand, involves a desire to deprive others of their success. Pathological jealousy, an extreme form of malicious envy, can lead to violence and is considered highly hazardous.
The MAOA gene, often called the 'warrior gene,' influences aggression by regulating neurotransmitters involved in anger. Mutations in this gene can lead to extreme aggression and criminal behavior. Additionally, testosterone exposure during fetal development, indicated by finger length ratios, correlates with adult aggression levels.
Childhood adversity, such as trauma, bullying, or abuse, can fundamentally alter brain areas responsible for generating and regulating anger. These experiences shape how individuals respond to stress and conflict, often leading to heightened aggression or difficulty managing anger in adulthood.
The concept of free will is debated, but changes in brain structure or function can significantly influence behavior. Some individuals may have little control over their actions due to neurological or genetic factors, while others may have more autonomy. Determining responsibility is complex and depends on where an individual falls on the spectrum of brain function.
Scientists are increasingly finding that behaviours once seen as depraved often have a direct physical cause. To find out more, Ian Sample hears from Guy Leschziner, a consultant neurologist and sleep physician at Guy’s and St Thomas’ hospital in London. His new book, Seven Deadly Sins: The Biology of Being Human, looks at the neurological basis of behaviours often dismissed as evidence of bad character or lack of willpower. Help support our independent journalism at theguardian.com/sciencepod)