Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.01.24.525342v1?rss=1
Authors: Ruscheinski, A., Reimler, A. L., Ewald, R., Uhrmacher, A. M.
Abstract:
linVar aggregates information about genetic variants and their relation to human diseases and forms a valuable resource for clinical diagnostics. The assessment of variants, e.g., as being benign or pathogenetic, changes over time. We collected variant classification histories of ClinVar releases and used those to derive discrete-time Markov chains to investigate the reclassification dynamics of variants in ClinVar in terms of transition probabilities between ClinVar releases and reclassifications.
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