cover of episode 275. Stop Mega-Dosing Vitamin D! Science Explained

275. Stop Mega-Dosing Vitamin D! Science Explained

2024/11/19
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Lucas Owen: 本期播客主要讨论了过量服用维生素D的潜在危险性。Lucas Owen认为,过量服用维生素D,即每日摄入量超过10000 IU,可能对健康造成不利影响。他建议大家检查自己维生素D补充剂的剂量,并强调对于大多数人来说,每日摄入1000-5000 IU维生素D是安全的,但仍需定期进行血液检测以监测维生素D水平。维生素D对免疫系统、骨骼健康和新陈代谢至关重要,因此定期检测至关重要。Lucas Owen还指出,维生素D实际上是一种激素,而非维生素,其过量服用存在重大风险。肝脏或肾脏功能异常会影响体内活性维生素D的产生。一项针对精英运动员的研究表明,过量服用维生素D会产生负反馈循环,降低体内活性维生素D的水平。研究显示,服用30000 IU或70000 IU维生素D3会增加血液中维生素D的非活性形式和活性形式,高剂量服用还会导致维生素D代谢产物升高,抑制非活性维生素D向活性形式的转化,形成负反馈循环。因此,与大剂量一次性服用相比,少量多次服用维生素D更好。大剂量服用维生素D会阻碍维生素D受体结合,降低血液中活性维生素D的水平。食物并非维生素D的良好来源,通过食物摄取维生素D难以满足每日需求。Lucas Owen建议,获取维生素D的最佳方式是通过阳光照射,其次是维生素D灯,最后是补充剂。只有在免疫系统受损或经血液检测证实的情况下才需要补充维生素D。

Deep Dive

Key Insights

Why should you avoid megadosing vitamin D?

Megadosing vitamin D, defined as doses above 10,000 IU in one serving, can lead to a negative feedback loop where the active form of vitamin D is inhibited, potentially causing a drop in its levels and affecting its benefits for immune system, bone health, and metabolic functioning.

What is the recommended daily intake of vitamin D for most adults?

The recommended daily intake of vitamin D for most adults is around 600 to 800 IU.

Why is sunlight the best source of vitamin D?

Sunlight is the best source of vitamin D because it allows your body to synthesize the vitamin naturally, and the amounts found in food sources are generally too low to meet daily requirements.

What happens when you abruptly stop taking high doses of vitamin D?

Abruptly stopping high doses of vitamin D can result in elevated levels of the inactive form and a drastic fall in the active form, which can take weeks to return to baseline levels.

Why is it important to get routine blood testing for vitamin D levels?

Routine blood testing is crucial to assess vitamin D levels accurately and ensure they are within safe limits, as there is no other way to determine if you are getting too much or too little.

What are the potential dangers of ultra high doses of vitamin D?

Ultra high doses of vitamin D can raise a metabolite that inhibits the conversion of inactive vitamin D to its active form, potentially leading to a decrease in the active vitamin D levels and associated health benefits.

What is the best form of vitamin D to supplement with?

Vitamin D3 is the best form of vitamin D to supplement with, as it is more effective and biologically active.

How can you gradually withdraw from vitamin D supplementation?

Gradual withdrawal from vitamin D supplementation is recommended to avoid drastic changes in vitamin D levels. This can be done by slowly reducing the dose over time rather than stopping abruptly.

Chapters
This chapter explores the potential dangers of megadosing vitamin D, defining megadosing as anything above 10,000 IU in supplemental form. It emphasizes the importance of regular blood tests to monitor vitamin D levels and highlights the crucial role of vitamin D in immune system, bone health, and general metabolic functioning.
  • Megadosing vitamin D is defined as exceeding 10,000 IU in a single serving.
  • Regular blood tests are crucial for monitoring vitamin D levels.
  • Vitamin D is essential for immune function, bone health, and metabolism.

Shownotes Transcript

In this solocast Lucas highlights the potential dangers of megadosing vitamin D.

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Disclaimer:

The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy) for more information.