Megadosing vitamin D, defined as doses above 10,000 IU in one serving, can lead to a negative feedback loop where the active form of vitamin D is inhibited, potentially causing a drop in its levels and affecting its benefits for immune system, bone health, and metabolic functioning.
The recommended daily intake of vitamin D for most adults is around 600 to 800 IU.
Sunlight is the best source of vitamin D because it allows your body to synthesize the vitamin naturally, and the amounts found in food sources are generally too low to meet daily requirements.
Abruptly stopping high doses of vitamin D can result in elevated levels of the inactive form and a drastic fall in the active form, which can take weeks to return to baseline levels.
Routine blood testing is crucial to assess vitamin D levels accurately and ensure they are within safe limits, as there is no other way to determine if you are getting too much or too little.
Ultra high doses of vitamin D can raise a metabolite that inhibits the conversion of inactive vitamin D to its active form, potentially leading to a decrease in the active vitamin D levels and associated health benefits.
Vitamin D3 is the best form of vitamin D to supplement with, as it is more effective and biologically active.
Gradual withdrawal from vitamin D supplementation is recommended to avoid drastic changes in vitamin D levels. This can be done by slowly reducing the dose over time rather than stopping abruptly.
In this solocast Lucas highlights the potential dangers of megadosing vitamin D.
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