Suffering is part of the human condition, except when it isn't.

I met a man at an ACX meetup once who claimed he has never felt anxiety, not even the littlest bit. His father was the same way, so maybe it's genetic.

Some people feel more pain than others. The “more pain” category includes some big demographic groups like redheads, who seem to feel some types of pain more intensely and may need up to 20% more anaesthetic, though their exact processing differences are complicated. But there are also various lesser-known genetic conditions that can make bizarre things - water, light touch, mild temperature changes - excruciatingly painful. The most exotic cause of this syndrome has to be platypus venom, which is both painful in and of itself and also seems to increase the body’s overall capacity to feel pain; for years after a platypus scratch, every tiny scrape will hurt worse than usual.

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Profile: The Far Out Initiative