Adenosine builds up the longer we are awake, creating a sleep drive or sleep hunger. It makes us feel sleepy and is blocked by caffeine, which is why we feel more alert after consuming it.
Caffeine acts as an adenosine antagonist, blocking the sleepiness signal by occupying the adenosine receptor slots, preventing adenosine from binding and making us feel sleepy.
Morning light exposure helps set the circadian rhythm by signaling to the central clock in the brain, ensuring proper timing of cortisol and melatonin release, which are vital for wakefulness and sleep.
Viewing sunlight around sunset can help protect against the negative effects of light later in the day, preventing disruptions to melatonin release and improving sleep quality.
Artificial light in the evening can delay the circadian clock, making it harder to fall asleep and disrupting sleep patterns. It can also suppress the release of dopamine, affecting mood and learning.
Certain forms of magnesium, like magnesium threonate, can enhance sleepiness and improve the ability to stay asleep by increasing neurotransmitters like GABA, which promote relaxation.
Naps, especially those under an hour, can provide a boost in energy and focus, helping to counteract the natural dip in alertness that occurs in the afternoon.
Yoga nidra is a form of meditation that helps train the nervous system to transition from heightened alertness to relaxation, making it easier to fall asleep when desired.
Our autonomic nervous system is more easily engaged in wakefulness than in sleep, making it harder to force ourselves to fall asleep due to the asymmetry between sympathetic and parasympathetic systems.
Epigenin can support the creation of a sleepiness state, helping to fall asleep and stay asleep by augmenting the effects of melatonin and other sleep-promoting neurotransmitters.
This is the second episode of Huberman Lab Essentials — short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes.
This Essentials episode offers insights into what makes us sleepy, helps us sleep soundly, and feel awake and alert. It covers a wide range of tools for anyone looking to improve their sleep and wakefulness, with the science and reasoning behind each tool explained.
Essentials will be released every Thursday, and our full-length episodes will still be released every Monday.
Access the full show notes for this episode at hubermanlab.com).
AG1: https://drinkag1.com/huberman)
Eight Sleep: https://eightsleep.com/huberman)
ROKA: https://roka.com/huberman)
00:00:00 Introduction to Huberman Lab Essentials
00:00:18 Understanding Sleep & Wakefulness
00:01:11 The Role of Adenosine & Caffeine
00:03:45 Circadian Rhythms & the Importance of Light
00:04:54 Morning Light Exposure & Cortisol
00:06:27 Sponsor: AG1
00:16:14 Evening Light Exposure & Melatonin
00:18:08: Sponsor: Eight Sleep
00:19:47 Managing Light Exposure for Better Sleep
00:28:03 The Benefits of Naps & Yoga Nidra
00:29:06 Sponsor: ROKA
00:34:38 Supplements for Sleep & Wakefulness
00:38:42 Conclusion & Final Thoughts