cover of episode Dr. Mary Claire Haver: How to Navigate Menopause & Perimenopause for Maximum Health & Vitality

Dr. Mary Claire Haver: How to Navigate Menopause & Perimenopause for Maximum Health & Vitality

2024/6/3
logo of podcast Huberman Lab

Huberman Lab

AI Deep Dive AI Chapters Transcript
People
A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
D
Dr. Mary Claire Haver
Topics
Andrew Huberman:对更年期的定义应重新审视,不能仅以最后一次月经来定义;对围绝经期和更年期女性的健康问题,包括心血管疾病、骨质疏松症等,应给予更多关注和研究;激素替代疗法(HRT)的益处和风险,以及最佳起始时间,需要进一步研究和明确;呼吁增加对女性健康的科研投入。 Dr. Mary Claire Haver:更年期是卵巢功能衰竭的标志,而非仅仅是月经停止;围绝经期激素水平波动剧烈,导致各种症状,包括月经紊乱、疲劳、心悸、情绪波动等;健康的生活方式,包括抗炎饮食、规律运动和充足睡眠,对改善更年期症状至关重要;激素替代疗法是治疗更年期症状,特别是潮热和骨质疏松的有效方法,但需根据患者的具体情况和年龄选择合适的剂量和方式;对激素替代疗法的误解和争议,以及其在心血管疾病和认知功能方面的作用,需要进一步澄清;补充其他激素,如孕激素和雄激素,可能对改善更年期症状有益;强调女性健康的重要性,并呼吁改进医学教育,增加对女性健康问题的关注。 Andrew Huberman:探讨了更年期和围绝经期的定义、症状、以及如何通过生活方式的改变和激素替代疗法来改善更年期症状;强调了女性健康倡议(WHI)研究的局限性及其对激素替代疗法认知的影响;讨论了激素替代疗法在不同年龄段的益处和风险,以及如何根据个体情况进行调整;探讨了其他激素,如雄激素在女性健康中的作用;关注了更年期对精神健康的影响,以及如何通过激素替代疗法和心理干预来改善精神健康状况;讨论了改善更年期症状的其他方法,包括饮食、运动、补充剂等;强调了对女性健康研究的投入不足,以及改进医学教育以更好地应对女性健康问题的必要性。 Dr. Mary Claire Haver:详细解释了围绝经期和更年期的激素变化机制,以及这些变化如何导致各种症状;介绍了评估内脏脂肪水平的方法,并强调了控制内脏脂肪对健康的重要性;讨论了不同类型的激素替代疗法,包括口服、贴片、凝胶和阴道环等,并分析了它们的优缺点;详细解释了激素替代疗法的益处和风险,以及如何根据患者的具体情况选择合适的治疗方案;讨论了更年期对心血管健康、骨骼健康、皮肤健康和精神健康的影响,以及如何通过生活方式的改变和药物治疗来改善这些问题;介绍了其他辅助治疗方法,包括补充剂、针灸等;强调了对女性健康研究的投入不足,以及改进医学教育以更好地应对女性健康问题的必要性。

Deep Dive

Chapters
Menopause is medically defined as one year after the final menstrual period, signifying the end of ovarian function and a significant decline in sex hormone production. This definition can be problematic as it excludes women without menstrual periods due to hysterectomies, IUDs, or other conditions. Menopause represents a much larger shift than the cessation of menstruation.
  • Menopause is the end of ovarian function.
  • Estradiol levels decline to less than 1% of reproductive levels.
  • Progesterone and testosterone levels also decline.

Shownotes Transcript

In this episode, my guest is Dr. Mary Claire Haver, M.D.), a board-certified OB/GYN and an expert on women’s health and menopause. We discuss the biology and symptoms of perimenopause and menopause and their effects on body composition, cardiometabolic health, mental health, and longevity. She explains the lifestyle factors, including nutrition, resistance training, sleep, and supplements, that can better prepare women for and improve symptoms of both perimenopause and menopause. We also discuss hormone replacement therapy (HRT) and whether HRT impacts the incidence of breast cancer or can affect cardiovascular health.

We also discuss contraception, cellulite, polycystic ovary syndrome (PCOS), and how to reduce the risk of osteoporosis. This episode is rich in actionable information related to what is known about menopause and perimenopause and the stages before, allowing women of all ages to best navigate these life stages.

For show notes, including referenced articles and additional resources, please visit hubermanlab.com).

Thank you to our sponsors

AG1: https://drinkag1.com/huberman 

AeroPress: https://aeropress.com/huberman 

Eight Sleep: https://eightsleep.com/huberman 

BetterHelp: https://betterhelp.com/huberman 

InsideTracker: https://insidetracker.com/huberman 

Timestamps

00:00:00 Dr. Mary Claire Haver

00:02:04 Sponsors: AeroPress, Eight Sleep & BetterHelp

00:06:26 Menopause, Age of Onset

00:09:50 Perimenopause, Hormones & “Zone of Chaos”

00:14:42 Perimenopause, Estrogen & Mental Health

00:20:04 Perimenopause Symptoms; Tool: Lifestyle Factors & Ovarian Health

00:25:26 Early Menopause, Premature Ovarian Failure; Estrogen Therapy

00:29:42 Sponsor: AG1

00:31:31 Contraception, Transdermal, IUDs; Menopause Onset, Freezing Eggs

00:38:18 Women’s Health: Misconceptions & Research

00:45:01 Tool: Diet, Preparing for Peri-/Menopause; Visceral Fat

00:48:31 Tools: Body Composition, Muscle & Menopause, Protein Intake

00:51:42 Menopause: Genetics, Symptoms; Tools: Waist-to-Hip Ratio; Gut Microbiome

00:58:22 Galveston vs. Mediterranean Diet, Fasting, Tool: Building Muscle

01:05:18 Sponsor: InsideTracker

01:06:29 Hot Flashes; Estrogen Hormone Replacement Therapy (HRT), Breast Cancer Risk & Cognition

01:15:36 Estrogen HRT, Cardiovascular Disease, Blood Clotting; “Meno-posse”

01:24:00 Estrogen & Testosterone: Starting HRT & Ranges

01:30:36 Other Hormones, Thyroid & DHEA; Local Treatment, Urinary Symptoms

01:37:57 OB/GYN Medical Education & Menopause

01:41:30 Supplements, Fiber, Tools: Osteoporosis “Prevention Pack”

01:46:53 Collagen, Cellulite, Bone Density

01:51:42 HRT, Vertigo, Tinnitus, Dry Eye; Conditions Precluding HRT 

01:55:27 Polycystic Ovary Syndrome (PCOS) & Treatment; GLP-1, Addictive Behaviors

02:01:55 Post-menopause & HRT, Sustained HRT Usage

02:04:58 Mental Health, Perimenopause vs. Menopause; Sleep Disruptions, Alcohol

02:09:09 Male Support; Rekindle Libido

02:12:46 HRT Rash Side-Effect; Acupuncture; Visceral Fat

02:16:24 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter

Disclaimer)