cover of episode Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

2024/2/19
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Huberman Lab

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A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
M
Mark D'Esposito
Topics
Andrew Huberman:探讨了执行功能和记忆在日常生活中的重要性,以及优化认知功能的策略。他还探讨了智能手机等技术对大脑的影响,以及如何通过行为和药物策略来改善认知功能。 Mark D'Esposito:详细解释了前额叶皮层在执行功能和记忆中的作用,以及多巴胺在工作记忆中的关键作用。他还讨论了创伤性脑损伤、脑震荡、阿尔茨海默病和帕金森病等疾病,以及如何通过行为和药物方法来恢复或减缓认知能力下降。他强调了优化大脑功能和健康的重要性,并分享了现代认知和记忆的理解以及可操作的工具。 Mark D'Esposito:详细解释了前额叶皮层在执行功能和记忆中的作用,以及多巴胺在工作记忆中的关键作用。他还讨论了创伤性脑损伤、脑震荡、阿尔茨海默病和帕金森病等疾病,以及如何通过行为和药物方法来恢复或减缓认知能力下降。他强调了优化大脑功能和健康的重要性,并分享了现代认知和记忆的理解以及可操作的工具。

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Chapters
El Dr. Mark D'Esposito, neurólogo y profesor de neurociencia y psicología en la Universidad de California, Berkeley, habla sobre los mecanismos cerebrales que subyacen a la cognición y las formas de memoria necesarias para la concentración, la productividad, la planificación y el logro de objetivos, y el aprendizaje.
  • La función ejecutiva es fundamental para todos los aspectos de nuestra vida diaria.
  • No hay separación entre la función ejecutiva y la memoria.
  • Este episodio proporciona una comprensión moderna de la cognición y la memoria, y herramientas prácticas para optimizar la salud y la función del cerebro.

Shownotes Transcript

In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function.

For show notes, including referenced articles and additional resources, please visit hubermanlab.com).

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Timestamps

(00:00:00) Dr. Mark D’Esposito

(00:02:08) Sponsors: Maui Nui, Joovv & Eight Sleep

(00:06:23) Brain & Frontal Lobes, Prefrontal Cortex, Executive Function

(00:10:31) Frontal Lobe Development, Children

(00:14:12) Rules, Context & Impulse Control; Learning & Goals

(00:21:45) Focus, Improving Executive Function

(00:26:04) Connections & Top-Down Signals

(00:29:02) Sponsor: AG1

(00:30:29) Frontal Lobe Injury; Emotional Regulation

(00:37:26) Smartphones, Social Media

(00:44:37) Working Memory, Dopamine

(00:52:59) Sponsor: LMNT

(00:54:22) Dopamine Levels & Working Memory, Cognitive Tasks, Genetics

(01:00:03) Bromocriptine & Working Memory, Dopamine

(01:06:21) Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests

(01:12:46) Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall

(01:19:27) Concussion, Traumatic Brain Injury (TBI)

(01:25:22) Sleep, TBI, Concussion & Executive Function; BrainHQ

(01:31:57) Aging & Frontal Executive System; Brain Health

(01:39:26) Tools: Brain Health & Boosting Executive Function, Books

(01:47:26) Alzheimer’s Disease, Genetics, Pharmacology

(01:51:48) Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s; Nicotine

(01:58:37) Estrogen & Dopamine, Cognition; Tool: Physical Exercise

(02:04:43) Tool: Mindfulness Meditation & Executive Function

(02:10:31) Brain Networks; Modularity

(02:17:08) Modularity, Brain Indices

(02:22:53) Psilocybin; Transcranial Magnetic Stimulation

(02:30:16) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

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