cover of episode Dr. Karen Parker: The Causes & Treatments for Autism

Dr. Karen Parker: The Causes & Treatments for Autism

2023/12/11
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Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
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Karen Parker
Topics
Andrew Huberman: 探讨了自闭症发病率增加的原因,可能是诊断技术改进和公众意识提高的结果,也可能是发病率实际增加。提出了关于自闭症谱系、早期干预、遗传因素和环境因素等问题。 Karen Parker: 详细解释了自闭症的诊断标准、遗传性和环境风险因素,以及目前和新兴的治疗方法。介绍了其团队在灵长类动物模型中进行的研究,发现了脑脊液加压素水平与自闭症社交症状严重程度之间的关联,并指出加压素可能成为一种新的自闭症治疗方法。还讨论了催产素在自闭症治疗中的作用,以及肠道微生物群对加压素和催产素的影响。 Andrew Huberman: 提出了关于自闭症谱系、早期干预、遗传因素和环境因素等问题,并探讨了催产素和加压素在自闭症中的作用,以及MDMA等其他方法在诱导神经可塑性方面的潜力。 Karen Parker: 详细解释了自闭症的诊断标准、遗传性和环境风险因素,以及目前和新兴的治疗方法。介绍了其团队在灵长类动物模型中进行的研究,发现了脑脊液加压素水平与自闭症社交症状严重程度之间的关联,并指出加压素可能成为一种新的自闭症治疗方法。还讨论了催产素在自闭症治疗中的作用,以及肠道微生物群对加压素和催产素的影响。

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Shownotes Transcript

In this episode, my guest is Dr. Karen Parker, Ph.D., professor of psychiatry and director of the Social Neurosciences Research Program at Stanford University School of Medicine. We discuss the biology of social connections and bonding in babies, children and adults. Dr. Parker explains our current understanding of autism and autism spectrum disorders: what they are, why the incidence of autism has increased so dramatically in recent years and both the current and emerging treatments for autism. We also discuss the condition formerly called “Asperger’s.” This episode ought to be highly relevant for anyone interested in child and human development, how social bonds form, and to those curious about autism and other spectrum conditions.

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Timestamps

(00:00:00) Dr. Karen Parker

(00:01:30) Sponsors: LMNT & Waking Up

(00:06:25) Autism, Frequency, Diagnosis

(00:10:41) Early Interventions; Heritability & Autistic Traits

(00:13:00) Autistic Spectrums; Studying Autism

(00:21:29) Environment, Risk Factors & In Utero Development

(00:28:01) Sponsor: AG1

(00:31:26) Oxytocin, Vasopressin, Social Behavior & Parent-Child Bonding

(00:43:240 Oxytocin in Humans; Social Features of Autism, Intranasal Oxytocin

(00:55:16) Oxytocin & Autism; Benefit & Risks

(01:06:30) Neuroplasticity & Autism; Early Intervention; Challenges of Early Diagnosis

(01:14:30) MDMA & Autism

(01:17:05) Vasopressin, Social Interaction; Voles & Parenthood

(01:27:07) Human Social Connection, Oxytocin Levels & Autism

(01:33:45) Primate Model of Social Impairment

(01:42:47) Preclinical Animal Models, Mouse & Primates

(01:47:11) Primates, Biomarkers & Social Connection; Vasopressin

(01:52:20) Vasopressin Levels & Autism, Children & In Utero

(02:03:06) Cerebral Spinal Fluid (CSF) & Vasopressin; Urination; Alternative Therapies

(02:10:32) Intranasal Vasopressin, Children, Autism & Social Responsiveness

(02:19:15) Vasopressin & Social Connection, Mechanism & Future Studies

(02:26:35) Gut Microbiome & Vasopressin; Scientific Funding

(02:34:52) Vasopressin Pathways, Social Behavior, Autism

(02:43:00) Vaccine Theory & Autism; Immunology

(02:54:06) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter

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