#19 - Dave Feldman: stress testing the lipid energy model
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In this episode, Dave Feldman, discusses his journey from software engineer to n=1 experimenter, his experience with low-carbohydrate diets, and his hypothesis that cholesterol levels are influenced by energy metabolism.

We discuss:

• Peter’s synthesis of Dave’s energy model [5:00)];

• Dave’s journey from software engineer to cholesterol enthusiast [15:00)];

• Standard blood panels, sterol panels, and what moves the needle when it comes to particle numbers [18:30)];

• Hyper-responders [20:00)];

• Lipoprotein transport [33:45];

• The lean mass hyper-responder phenotype [47:30];

• The progression of atherosclerosis, CAC, and CIMT [52:30];

• Testing for oxidized LDL [55:30];

• All-cause mortality and clinical endpoints [1:01:15];

• What does “LDL as causal” mean? [1:05:15];

• Dave’s low carb cholesterol challenge and drug & genetic study qualifications [1:13:15];

• If all other markers are in an healthy range, but LDL-P is high, is the patient at risk? A couple of case studies, and a self-experiment [1:27:30];

• Peter’s three-day exercise and ketosis experiment [1:41:00)];

• What are remnant lipoproteins? [1:45:00)];

• What might cause lean mass hyper-responders to have higher LDL particle numbers? [1:53:30];

• A case study from Dave of a lean mass hyper-responder [1:56:30];

• Mass balance and cholesterol flux [2:05:30];

• Can a higher degree of cholesterol explain the lean mass hyper-responder phenotype? [2:10:00)];

• Peter’s LDL during his keto-fast-keto experiment [2:13:30];

• Does substituting saturated fats with monounsaturated fats lower LDL-P and LDL-C? [2:15:45];

• Dave’s carb-swap experiments [2:22:15];

• Dave’s carotid intima-media thickness tests [2:41:15];

• Looking for studies that stratify for high HDL-C and low TG alongside low and high LDL-C [2:53:00)]; and

• More

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