How Silent Inflammation Accelerates Aging with Dr. David Furman
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This episode is brought to you by Rupa Health), BiOptimizers), and InsideTracker).

If you’re interested in health, you’ve heard the term inflammation quite a bit. But did you know there are different kinds of inflammation? Some of them are more alarming than others. Acute inflammation happens when you cut your finger and it gets red and a little swollen. This is helpful inflammation and usually resolves in about a week. But the inflammation that naturally happens as we age, called sterile-inflammation, sets us up for less resiliency against things like autoimmunity, cancer, and other forms of chronic disease. 

Today, I’m excited to dive deep into the topic of inflammation and its role in aging with Dr. David Furman. Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans.

This episode is brought to you by Rupa Health, BiOptimizers, and InsideTracker.

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Here are more details from our interview (audio version / Apple Subscriber version):

• The origins of Dr. Furman’s unique thinking about the immune system and aging (7:21 / 3:58) 

• Types of inflammation (11:13 / 8:02) 

• How systemic chronic inflammation drives all of the hallmarks of aging (13:32 / 10:30) 

• Causes of inflammation (18:24 / 13:46) 

• The immunome and the 1000 Immunomes Project (26:31 / 21:14) 

• How inflammatory age can be used to predict disease (33:13 / 27:12) 

• Predicting frailty in individuals years before they become frail (35:54 / 30:37) 

• Newly discovered biomarkers that can be used for early detection of age-related disease (38:54 / 32:02) 

• How the iAge test will be used in the future (47:58 / 43:42) 

• Learnings from centenarians (59:24 / 54:12)

Learn more about the 1000 Immunomes Project).

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