Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.07.18.549619v1?rss=1
Authors: VanderDoes, J., Marceaux, C., Yokote, K., Asselin-Labat, M.-L., Rice, G., Hywood, J. D.
Abstract:
Tumor microenvironments (TMEs) contain vast amounts of information on patient's cancer through their cellular composition and the spatial distribution of tumor cells and immune cell populations. Exploring variations in TMEs among patients and cancer types, as well as determining the extent to which this information can predict variables such as patient survival or treatment success with emerging immunotherapies, is of great interest. Moreover, in the face of a large number of potential spatial cell interactions to consider, we often wish to identify specific interactions that are useful in making such predictions. We present an approach to achieve these goals based on summarizing spatial relationships in the TME using spatial K functions, and then applying functional data analysis and random forest models to both predict outcomes of interest and identify important spatial relationships. This approach is shown to be effective in simulation experiments. We further used the proposed approach to interrogate two real data sets of Multiplexed Ion Beam Images of TMEs in triple negative breast cancer and lung cancer patients. The methods proposed are publicly available in a companion R package funkycells.
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