Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.02.13.528380v1?rss=1
Authors: Li, W., Mirone, J., Prasad, A., Miolane, N., Legrand, C., Dao Duc, K.
Abstract:
Conventional dimensionality reduction methods like Multidimensional Scaling (MDS) are sensitive to the presence of orthogonal outliers, leading to significant defects in the embedding. We introduce a robust MDS method, based on the geometry and statistics of simplices formed by data points, that allows to detect orthogonal outliers and subsequently reduce dimensionality. We validate our methods using synthetic datasets, and further show how it can be applied to a variety of large real biological datasets, including cancer image cell data and human microbiome project data.
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