Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.02.28.530481v1?rss=1
Authors: Zeng, Y., Ye, W., Stutheit-Zhao, E. Y., Han, M., Bratman, S. V., Pugh, T. J., He, H. H.
Abstract:
Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) has emerged as a promising non-invasive technology to detect cancers and monitor treatments. Several bioinformatics tools are available for cfMeDIP-seq data analysis. However, an easy to implement and flexible pipeline, particularly, for large-scale cfMeDIP-seq profiling, is still lacking. Here we present the MEDIPIPE, which provides a one-stop solution for cfMeDIP-seq data quality control, methylation quantification and sample aggregation. The major advantages of MEDIPIPE are: 1) it is easy to implement and reproduce with automatically deployed execution environments; 2) it can handle different experimental settings with a single input configuration file; 3) it is computationally efficient for large-scale cfMeDIP-seq profiling data analysis and aggregation.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
