Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.03.16.533065v1?rss=1
Authors: Avram, O., Levy Karin, E., Corander, J., Oren, Y., Pupko, T.
Abstract:
Selective sweeps occur when a beneficial mutation spreads rapidly throughout the population due to natural selection. Searching for selective sweeps has proved to be one of the most fruitful ways to detect the footprints selection leaves on the genome. With a plethora of detection tools, the study of selective sweeps in eukaryotic systems is a well-established field of research. However, the search for fragment-specific selective sweeps among bacterial strains received little to no attention so far. In our work, we demonstrate that inter-strains locus-specific selective sweeps can be detected in bacteria. We introduce the SINCOPA algorithm, the first phylogeny-based method for soft and incomplete selective sweeps detection. We use SINCOPA to explore inter-strains locus-specific selective sweeps in a dataset containing more than 500 microbial genomes. We observe strong evidence in several loci for locus-specific selective sweeps including genes involved in biofilm formation and others that are related to coping with various unfavorable environmental conditions. SINCOPA is freely accessible as a user-friendly web server application at https://sincopa.tau.ac.il/.
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