Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.02.19.529160v1?rss=1
Authors: Sakuma, K., Koike, R., Ota, M.
Abstract:
AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family whose structure was surprisingly novel, showing an atypical topology for P-loop NTPase proteins, noticeable two-fold symmetry, and independent two pairs of putative active sites. Our finding proves structural data mining is a powerful approach to identifying undiscovered protein families.
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