Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.07.06.547960v1?rss=1
Authors: Barik, S. K., Turuk, J., Giri, S., Pati, S.
Abstract:
The codon bias usage study of the 33 Vitamin D Receptor (VDR) genes of the Multiple sclerosis and Diabetes-1 patients were characterized. Various computational tools were used to find out the codon usage pattern of the VDR genes in both group of patients. The base compositions, nucleotide substation rates, codon adaptation index, hydrophobic nature of the amino acids of VDR gene of both group of patients were analysed. The analysis of the synonymous codon usage pattern of the genes would helpful in the heterologous expression of the VDR genes leads to codon optimizations in Multiple Sclerosis and Diabetes-1 patients. The codon usage bias analysis of the VDR gene of the Multiple sclerosis and Diabetes-1 patients through computational approach determined the pattern of VDR gene expression and evolution during the acquiring of the disease of the patients.
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