Lasker Laureate Daniel Koshland’s work changed our understanding of how enzymes interact with their substrates. In this 1998 interview with Robert Tjian, a fellow professor at Berkeley, Koshland talks about how the scientific community reacted to his “induced fit” model of enzyme-substrate interaction, and discusses his decades-long career, which spanned work as a scientist, an administrator, and a journal editor. Read about the 1998 Albert Lasker Special Achievement Award in Medical Science: https://laskerfoundation.org/winners/science-communication-and-education/)