Practical Radiation Oncology executive editor Julia White, MD, hosts a conversation on the use of accelerated treatment schedules for post-lumpectomy breast cancer patients. Dr. White is joined by Melissa Mitchell, MD, PhD of MD Anderson Cancer Center and Frank Vicini, MD, of GenesisCare. Dr. Mitchell and Dr. Vicini discuss the frequency and criteria for use of accelerated treatment in their practices, the available data regarding efficacy, toxicity, and cosmesis outcomes, how these treatments align with ASTRO guidelines, and what they think the future may hold for accelerated fractionation schedules.