Episode 124.0 – Metformin-Associated Lactic Acidosis
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This week we discuss a quick case leading into the management of MALA.

        [https://media.blubrry.com/coreem/content.blubrry.com/coreem/Podcast_Episode_124_0_Final_Cut.m4a](https://media.blubrry.com/coreem/content.blubrry.com/coreem/Podcast_Episode_124_0_Final_Cut.m4a))         
  
  
				
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				Tags: [Metformin](https://coreem.net/tag/metformin/)), [Toxicology](https://coreem.net/tag/toxicology/))				
				



  
              ## Show Notes

     **Take Home Points**

In patients with shortness of breath and clear lungs, consider metabolic acidosis with respiratory alkalis as a potential cause

Suspect MALA in any patient on metformin who presents with abdominal pain, nausea and vomiting and/or AMS

Patients with MALA will have a low pH, a high-anion gap metabolic acidosis and high lactate levels

Call your tox consultant to assist with management which will focus on fluid resuscitation with isotonic bicarbonate and dialysis

Read More

Bosse GM. Antidiabetics and Hypoglycemics. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank’s Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015. Link) Accessed October 31, 2017

LITFL: Metformin-Associated Lactic Acidosis)

LITFL: Metformin)

The Poison Review: 6 Pearls About Metformin and Lactic Acidosis)

Read More)