cover of episode What is ‘mirror life’ and why are scientists sounding the alarm?

What is ‘mirror life’ and why are scientists sounding the alarm?

2025/2/13
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Ian Sample
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Kate Ademala
M
Madeleine Finlay
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@Madeleine Finlay : 我介绍了镜像生命的概念,指出自然界倾向于选择单一手性的分子构建生命,而科学家试图创造镜像生命。然而,科学家们也发出了警告,认为创造镜像生命可能带来风险。我强调了镜像细胞应该停留在理论层面,不应成为现实。 @Ian Sample : 我解释了分子手性的重要性,指出分子的手性决定了它们与其他分子的相互作用方式。镜像分子具有独特的性质,例如镜像蛋白质可能对免疫系统隐形,可用于开发新型药物。此外,镜像微生物可用于生物反应器,因为它们对病毒具有抵抗力。创造镜像生命有助于我们更深入地理解生命的本质,并可能发现宇宙中存在镜像生命。 @Kate Ademala : 我分享了我对镜像生命研究的看法转变。最初,我对镜像生命研究充满热情,但后来我意识到其潜在的危险。镜像生物体不被免疫系统识别,可能导致无法控制的感染。我强调,镜像微生物可能逃脱实验室,感染植物、动物和人类,因为免疫系统无法对抗它们。尽管对未能进行镜像生命研究感到失望,但我为能够认识到其中的担忧而感到自豪。

Deep Dive

Chapters
This chapter introduces the concept of mirror life and chirality. It explains how molecules can exist in mirror-image forms and how this 'handedness' is crucial for biological interactions. The chapter uses the analogy of a left hand not fitting a right-handed glove to illustrate how molecules with different chirality won't interact properly.
  • Molecules can exist in mirror-image forms.
  • Life on Earth prefers one orientation of molecules.
  • Chirality determines how molecules interact.
  • Mirror molecules would not interact correctly with normal molecules.

Shownotes Transcript

Recently, a group of world-leading scientists called for a halt on research to create ‘mirror life’ microbes amid concerns that the synthetic organisms would present an ‘unprecedented risk’ to life on Earth. Ian Sample tells Madeleine Finlay about why this work initially seemed exciting for scientists and what the risks of it continuing could be. And Kate Adamala, assistant professor of genetics, cell biology and development at the University of Minnesota, describes what made her change her mind about pursuing her own research on mirror cells. Help support our independent journalism at theguardian.com/sciencepod