194. Animal-based vs. Ray Peat diet, a conversation with Georgi Dinkov
Paul Saladino MD podcast
Deep Dive
What is the difference between sucrose and high fructose corn syrup (HFCS) in terms of metabolic effects?
There is no metabolic difference between sucrose and pure HFCS. However, some HFCS-sweetened drinks contain unhydrolyzed starch, which can significantly increase the caloric load and trigger inflammatory reactions if absorbed into the bloodstream.
How does chronic stress contribute to diabetes and obesity?
Chronic stress elevates cortisol, which stimulates lipolysis and blocks glucose uptake and metabolism. This leads to insulin resistance and diabetes, as well as increased fat storage, especially in the abdominal area.
Why are ketogenic diets often not sustainable long-term?
Ketogenic diets can initially help with weight loss, but over time, they can elevate cortisol and increase lipolysis, leading to a catabolic state. This can cause muscle loss and insulin resistance, making it difficult to maintain or return to a normal diet without weight gain.
What is the Randle Cycle and how does it affect glucose and fat metabolism?
The Randle Cycle is a metabolic process where the availability of free fatty acids inhibits glucose uptake and utilization. This can lead to a buildup of pyruvate and lactate, and ultimately, the conversion of glucose to fat rather than its complete oxidation to ATP.
Why should starchy foods be avoided, and what are better carbohydrate sources?
Starchy foods can increase the production of endotoxins in the gut, leading to inflammation and serotonin production. Better carbohydrate sources include simple sugars like honey and ripe fruits, which are more easily absorbed and do not trigger the same inflammatory response.
What is the role of serotonin in mental health and chronic diseases?
Serotonin is primarily a metabolic regulator that inhibits oxidative phosphorylation, especially in the brain. High serotonin levels can lead to depression, psychosis, and fibrosis, which is a precursor to cancer. Serotonin antagonists have shown promise in treating these conditions.
What are the benefits of eating organ meats in a diet?
Organ meats like liver and heart are rich in essential nutrients like vitamins A, B, and minerals like copper and zinc. They provide protective factors against stress and inflammation, and can help balance the amino acid profile of the diet, which is important for metabolic health.
Why is a balanced intake of collagen and muscle meat important?
Muscle meat is high in tryptophan, methionine, and cysteine, which are anti-thyroid and can be harmful in excess. Collagen, found in tendons and skin, contains glycine and proline, which can balance these effects and reduce inflammation. Ground beef and organ meats can provide a more balanced nutrient profile.
What are some reliable markers to test for chronic inflammation and cortisol levels?
Markers like CRP, ESR (erythrocyte sedimentation rate), and whole blood serotonin are reliable indicators of chronic inflammation. For cortisol, testing both AM and PM cortisol levels in the blood or using 24-hour urinary cortisol can provide a comprehensive picture.
How does the Ray Peat diet differ from traditional ketogenic diets?
The Ray Peat diet emphasizes the importance of carbohydrates, particularly from fruit and honey, to support thyroid function and reduce stress hormones. It also focuses on limiting polyunsaturated fats and including organ meats to provide essential nutrients and protect against metabolic issues.
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