Optimizing Nitric Oxide for Longevity: A Conversation with Dr. Nathan Bryan - Episode 215
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Are diet and lifestyle always sufficient for enhancing nitric oxide? Welcome to another episode of the Gladden Longevity Podcast with Dr. Jeffrey Gladden and Dr. Nathan Bryan! Dr. Bryan holds a Biochemistry B.Sc. from the University of Texas and a Ph.D. from Louisiana State University School of Medicine. A former Kirschstein Fellow at Boston University, he joined the University of Texas Health Science Center faculty in 2006. With 20 years in nitric oxide research, he's secured numerous patents. As an entrepreneur, he founded successful companies like HumanN, Inc. and serves as CEO of Bryan Therapeutics, Inc., focused on nitric oxide therapies for heart disease, Alzheimer's, and diabetic wounds. Dr. Bryan is an influential figure in molecular medicine and nitric oxide biochemistry. In this episode, they talk about all things nitric oxide and how your body cannot and will not heal or perform without adequate nitric oxide. They also speak about how things like mouthwash, fluoride, and drug therapy such as antacids lead to loss of NO production and how there is a need to supplement nitric oxide due to Western diet and hygienic practices. Why should you stop using mouthwash?   Dr. Gladden has known Nathan for over ten years and says he is a genius. (00:40) Steven is still shocked at how mouthwash affects our health. (1:21) Steve shares how he rediscovered a cardio workout. (2:50) Dr. Gladden likes the idea of using twenty-seven as a benchmark for his youthfulness. (04:39) Dr. Gladden shares Nathan’s profile. (6:20) Nathan reveals he got a Ph.D. in Molecular Physiology. (8:09) Surprised Nobel Prize winner discusses nitric oxide and says there is so much we don’t know. (09:55) Nathan said his PhD thesis involved how to detect concentrated levels of nitric oxide. (12:05) Nitric oxide is the most potent anti-inflammatory molecule in the human body. (14:38) Nathan talks about what nitric oxide does. (16:00) Nitric oxide levels are important for cardiovascular health. (18:11) Dr. Gladden asks Nathan to share how Viagra can affect nitric oxide. (21:23) Dr. Gladden says that an issue with the endothelium shows the onset of cardiovascular disease. (23:53) Nathan reveals that you have to understand the signaling pathways to optimize performance. (26:45) Nathan tells listeners what they should not do. (28:05) Nathan reveals that fluoride is harmful. (30:19) Nathan advises people to get off fluoride and antacids. (32:50) Optimizing how the human body makes nitric oxide production systems and diet is important. (34:00) Bacteria in your mouth are doing you a favor to keep your arteries healthy. (36:12) Not all foods are rich in dietary nitrates. (38:36) Don't get caught up in an organic fad, avoid herbicides and pesticides, and understand nutrient deficiencies in the American diet. (40:38) Some Mediterranean herbs are really helpful for arterial health. (43:08) Leafy greens are good, but you have to check the quality of the leafy greens, too. (45:40) Nathan gives an example of a nitric oxide that can be ingested through the mouth. (48:03) The triple play effect of delivering nitric oxide. (51:35) Nathan details what they do with beet products. (53:45) Eighty-five percent of nitrates that come from diet come from vegetables. (55:46) Nitric oxide is always there in pathology but does not necessarily mean it is causing the pathology. (57:44) Nathan explains how nitric oxide is crucial for mitochondrial biogenesis.(1:01:45) Dr. Gladden notes that it is never only about one thing. (1:03:46) Nathan thinks nitric oxide drug approval is expected in 3-5 years. (1:09:02) Nathan shares that he takes his chlorella and spirulina every morning he wakes up. (1:14:24)   To know more about Nathan: www.N1O1.com) www.drnathansbryan.com) www.NO2U.com) www.nitricoxideinnovations.com) Instagram:  @drnathansbryan Twitter:  @drnitric LinkedIn:  drnathansbryan   Affiliate Link/Code: "Gladden10" for 10% off and free shipping to the listener at this link).