0:00 Introduction1:29 Ness’ journey to becoming an entrepreneur and first-time founder.5:37 Discussing CRISPR Therapeutics and its application in treating sickle cell disease.7:43 Exploring the potential of RNA therapies and Ness’ work at Korro Bio.11:29 Balancing scientific discovery with commercial viability in alpha-1 antitrypsin therapies for lung and liver diseases.14:55 Creating a vision, setting realistic goals, and managing capital in early-stage biotech companies.19:42 Differentiating biotech companies that use the same platform technologies, such as RNA editing.24:19 Addressing regulatory barriers in drug development and exploring phenotypic manifestations of diseases.28:53 Discussing bottlenecks in biotechnology, including drug delivery, regulation, patient segregation, and reimbursement.33:02 Exploring how to price cures based on the financial burden saved by the healthcare system.35:31 Sharing insights on Khosla Ventures’ investment in OpenAI and the impact of AI in biotech.41:28 Discussing the role of AI in identifying drug targets, increasing impact rates, and enhancing patient safety.43:32 Introducing Ness’ podcast, Between the BioTech Waves).46:23 Discovering what advancements in biotechnology Ness is most excited about.51:40 Closing remarks.Please consider rating and reviewing) us on your chosen podcast listening platform!