01:15 - Introductions 02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career04:56 - Our current understanding of non-coding genome grammar07:40 - Is there a missing piece to the common variant, common disease paradigm?10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs) 12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?14:25 - The potential of machine learning16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases20:19 - Nadav’s experience of starting a company 24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing26:04 - How engineering fat cells can starve cancer32:08 - What’s on the horizon for Nadav’s lab?34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels 38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans40:33 - Closing remarks
