0:00 Intro to The Genetics Podcast01:00 Welcome to Marco02:00 The areas Marco focused on during his academic career and what motivated him to found his first company03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology06:01 How to get a clearer picture of the ageing process within a tissue or cell and if new technologies like single cell genomics can aid this process11:08 Catalyst or cause? Understanding the role of cellular senescence in disease and how it impacts treatment pathways12:54 The challenges of building a company that addresses an area of biology which sits at the core of so many diseases and disease types16:17 Deciding on which therapeutic modality to target when using a platform biology approach17:57 Identifying the most effective stage at which to intervene in the senescence process and if this changes dependent upon organ system or disease area24:33 How another company founded by Marco, Turnbio, uses a different approach by focusing on turning back the biological clock rather than understanding the ageing process and intervening31:08 Addressing if both preventative and intervention approaches are required to comprehensively treat or cure a disease35:39 Whether there is potential to develop core therapeutics which can have a system-wide effect and address all-cause ageing40:12 Why ‘biohacking’ therapies can present a risk to the field of ageing biology as a whole, as well as to individuals 41:18 The developing area of science or technology Marco is most excited about and which he believes is going to have a significant impact in the coming years 43:23 Closing remarks Find out morewww.rubedolife.com)
