0:00 Intro0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science5:30 Opportunities for research and drug development in the realm of somatic science9:20 Somatic evolution and how it provides valuable insights into disease mechanisms12:30 Advantages and disadvantages of studying germline genome-wide association studies (GWAS) versus somatic genomes for target and drug discovery17:00 How germline and somatic mutations can complement one another when studying conditions like MASH, autoimmune disorders, infectious diseases, and more21:10 The method behind obtaining and analysing tissue samples24:00 The importance of high resolution for somatic variation29:30 “The genetics superhero”: How somatic variations can rescue maladaptive germline mutations32:00 How to obtain tissue samples of hard-to-reach areas of the body, like the brain33:00 How somatic genome can increase the scale of DNA data available 36:00 Best practices for scientific entrepreneurship44:50 Jake’s predictions for the next big breakthroughs in genetics and precision medicine48:20 Closing remarksPlease consider rating and reviewing) us on your chosen podcast listening platform!
