0:00 Introduction01:00 Chris’ background and career to date02:10 What is the Enigma Project?04:48 How is genetics being applied to drug discovery today and how does proteomics fit in?09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up10:57 54k UK Biobank participants tested - discussion of findings14:33 The project has carried out GWAS on nearly 3k proteins15:18 Are there plans to scale the project and what do the team hope to discover through larger scale work?18:10 Which areas of biology has the project provided a good insight into and which have proved more challenging19:30 Are there projects of a similar scale where it would be possible to focus more on neuroscience?21:31 Is reaching numbers akin to 100 million whole genomes required to fully leverage genetic data in drug discovery?25:00 Causal or correlated? Medelian randomisation as an important tool for drawing the link from gene to protein and identifying relevant phenotypes27:12 The causal proteins for the majority of neurological diseases are not differentially or cross sectionally changed 28:50 The future prospects of serial sampling and what is the potential value vs logistical burden31:05 Imaging derived phenotypes: Integration of brain scan data with genetics32:32 How well can brain organoids or other kinds of cellular systems match what’s going on in the actual brain?35:30 The most exciting developments in the field we might see in the next couple of years37:45 Closing remarksPlease consider rating and reviewing) us on your chosen podcast listening platform!
