cover of episode The surprising truth about histamine intolerance

The surprising truth about histamine intolerance

2024/2/15
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ZOE Science & Nutrition
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Dr. Will Bulsiewicz
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Jonathan Wolff
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Jonathan Wolff：探讨了组胺不耐受这一新兴研究领域，以及人们对其缺乏了解和治疗方法。 Dr. Will Bulsiewicz：详细解释了组胺在人体中的重要作用，以及组胺不耐受与过敏反应的区别。他阐述了组胺的产生过程，从组氨酸到组胺的转化，以及小肠中二胺氧化酶（DAO）在中和组胺中的作用。他还解释了组胺中毒（scombroid鱼中毒）和组胺不耐受的区别，前者是由于摄入高组胺食物引起的急性反应，而后者是慢性疾病，可能由看似正常的食物引起。Dr. Will Bulsiewicz 详细描述了组胺不耐受的症状，强调了其多样性和对诊断的挑战。他建议采用低组胺饮食进行诊断，并解释了低组胺饮食的原则，包括选择新鲜食物、避免高温烹调和发酵食物等。他还讨论了组胺不耐受的治疗方法，包括补充DAO酶和修复肠道屏障。他特别提到了发芽豆类作为DAO的良好来源，以及改善肠道健康对缓解组胺不耐受症状的重要性。最后，他强调了低组胺饮食的临时性，以及改善肠道健康后恢复对各种食物耐受性的可能性。 Dr. Will Bulsiewicz：详细解释了组胺在人体中的重要作用，以及组胺不耐受与过敏反应的区别。他阐述了组胺的产生过程，从组氨酸到组胺的转化，以及小肠中二胺氧化酶（DAO）在中和组胺中的作用。他还解释了组胺中毒（scombroid鱼中毒）和组胺不耐受的区别，前者是由于摄入高组胺食物引起的急性反应，而后者是慢性疾病，可能由看似正常的食物引起。Dr. Will Bulsiewicz 详细描述了组胺不耐受的症状，强调了其多样性和对诊断的挑战。他建议采用低组胺饮食进行诊断，并解释了低组胺饮食的原则，包括选择新鲜食物、避免高温烹调和发酵食物等。他还讨论了组胺不耐受的治疗方法，包括补充DAO酶和修复肠道屏障。他特别提到了发芽豆类作为DAO的良好来源，以及改善肠道健康对缓解组胺不耐受症状的重要性。最后，他强调了低组胺饮食的临时性，以及改善肠道健康后恢复对各种食物耐受性的可能性。

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Histamine intolerance is a growing area of research, affecting many who may not be aware they have it. Dr. Will Bulsiewicz discusses the condition and potential treatments.

Shownotes Transcript

We've probably all heard of “antihistamines,” medications that can ease symptoms of hay fever and other allergies. 

But what is “histamine”? It’s a vital chemical that our bodies produce, and it plays a role in a number of functions that support our health. 

Histamine intolerance seems to be increasingly common, but it’s difficult to diagnose. Some people may not be aware that they have it or how to treat it.

In today’s episode of ZOE Science & Nutrition, Jonathan speaks with Dr. Will Bulsiewicz, ZOE’s U.S. medical director, to learn more about this flourishing area of research — and the best ways to identify and treat histamine intolerance.

Will is a board-certified gastroenterologist, and New York Times bestselling author of the microbiome book Fiber Fueled.

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Mentioned in today’s episode: 

- Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability) published in Journal of Functional Foods

- Histamine and histamine intolerance) published in The American Journal of Clinical Nutrition

- Histamine intolerance: The current state of the art) published in Biomolecules

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Episode transcripts are available here).