cover of episode How to transform your health in midlife | Rich Roll and Prof. Tim Spector

How to transform your health in midlife | Rich Roll and Prof. Tim Spector

2025/2/13
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@Rich Roll : 我在20多岁时与药物和酒精作斗争,后来在31岁时戒酒。在专注于重建事业的过程中,我忽视了自己的健康和福祉,饮食和生活习惯仍然像酗酒一样,用食物来麻痹自己的情绪状态。在40岁前,我超重50磅,久坐不动,爬楼梯时感到气喘吁吁,这让我意识到需要改变生活方式。我意识到需要做出重大改变,并且有改变的意愿,因为我之前有过戒酒的成功经验,知道迅速采取行动的重要性。我需要为我的生活方式进行“排毒”,尝试各种食物和饮食,从而开始了我的转变之旅。以前我的饮食主要是快餐和外卖,包括披萨、汉堡、薯条等。我尝试过各种饮食,包括旧石器饮食和素食,但最终选择了纯素饮食,尽管一开始我很不情愿,但结果却出乎意料。我主要吃天然状态的植物性食物,限制加工食品和油的摄入,并尽可能多地摄入各种植物性食物。我吃很多蔬菜水果smoothies,以深色绿叶蔬菜为基础,还吃大量的豆类和藜麦,注重饮食的多样性。在7到10天内,我的精力水平显著提高,同时也开始感到充满希望。饮食改变后,我不再感到昏昏欲睡,睡眠质量也提高了,这降低了我的压力水平,改善了我的认知和解决问题的能力。我的生活几乎所有方面都得到了改善,这让我有热情继续学习如何正确地做到这一点,并使其适应我的生活。我在40岁时做出的改变彻底改变了我的生活,也改变了我对生活的看法。我们都拥有巨大的潜力,只要我们改变观念,善待身体,身体也会善待我们。

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Rich Roll, once an overweight junk-food addict, transformed his health after turning 40. He shares his journey from addiction to becoming an ultramarathoner, highlighting the importance of small, incremental changes and the surprising impact on mental health and energy levels. Professor Tim Spector adds the perspective of the gut microbiome's role in this transformation.
  • Rich Roll's midlife health transformation from junk food addiction to ultramarathon fitness.
  • The rapid positive effects on mood and energy levels after dietary changes.
  • The importance of small, incremental changes and building upon successes.
  • The connection between gut health, mood, and mental clarity.

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Welcome to ZOE Science and Nutrition, where world-leading scientists explain how their research can improve your health. Rich Roll is one of the 25 fittest men in the world, according to Men's Fitness magazine. But on the eve of his 40th birthday, he was an overweight junk food addict on the brink of a heart attack. But Rich made a radical decision to transform his life. He turned the tide in an age where many fear it's too late.

New research shows that midlife is the crucial moment to transform your health. A lot of things change around this age, and one such change happens in the community of organisms in your gut known as the microbiome. With the right intervention, your microbiome can slow age-related decline. You can transform your gut into a pharmacy that prescribes you the medicine that you need to age well. Today's guest, Rich Roll, is proof that you can transform your health even slightly later in life.

He fuels his ultramarathon fitness by eating only plants. Through his number one best-selling memoir and his health podcast, Rich inspires millions. Rich is joined today by Professor Tim Spector, who's a pioneer in the new field of gut microbiome research. Tim is one of the world's top 100 most cited scientists, a professor of epidemiology, and my scientific co-founder at ZOE. You'll finish today's episode with the tools you need to transform your health, no matter your age.

And if transforming your health is something you're interested in, and I'm guessing it is as you're listening to this podcast, do check out Zoe's Personalized Nutrition Program. Because committing to a change is easier when the change feels exciting. And what's more exciting than eating more of the foods you love? The Zoe app gives you a list of hundreds of delicious foods that are proven healthy to your unique biology. We take your unique Zoe test results. We combine them with our science to recommend the healthiest foods for you.

Here at Zoe, we study the world's largest gut microbiome database. And our data shows that when you eat a greater variety of foods, your gut will take better care of you. That's why we believe in abundance through variety, not restriction. Doesn't that sound like a change that's easier to commit to? Visit Zoe.com to sign up for our personalized nutrition membership today. Speaking of variety, we also just released a plant-based supplement that packs 30 plants into one crunchy scoop.

It's called Daily 30, and you can sprinkle it on any meal for a science-backed boost. Okay, let's get on with today's episode with Rich Roll and Professor Tim Spector. Rich, thank you for joining me today. Very happy to be with you guys today. Thanks for having me. And Tim, delighted to have you as well. Great to be here.

We like to always kick off our show here at Zoe with a rapid fire Q&A with questions from our listeners. And we have very strict rules, Rich. You can say yes or no, or if you have to, a one sentence answer. You willing to give it a go? Yeah. As a long form podcaster, this is going to be challenging, but I'm up for the challenge. We know you can do it. Rich, is 40 too late to transform your health? No. No.

At almost 60 years old, are you healthier than you were in your 30s? Absolutely, yes. Tim, is midlife too late to transform your gut microbiome? No. Can the food you eat increase your rate of aging? Yes. And finally, Rich, and you can have a whole sentence, what's the biggest misconception when it comes to changing your health during midlife?

Rome wasn't built in a day. It doesn't happen overnight. And it's really about making small incremental changes and building upon them. And I think if you devote yourself to that process, you'll be able to change in ways that might astonish you. That's my experience.

I love that and I think just that itself explains why you're an inspiration to a lot of people both in terms of that sort of motivational message and also because you're a plant-based ultra-endurance athlete. It's all a bit daunting if I'm honest as somebody who is the opposite of an ultra-athlete, whatever that is. We had a lot of people who actually specifically asking about tips on developing the willpower to make change.

So normally with this podcast, we're very focused on trying to educate people so they can make better food choices for their health based on their latest science. But I think sometimes for all of us, food doesn't really feel like a choice. It can feel like a craving that has to be met right now. And I know you've developed a lot of insights from your own journey with addiction and recovery. You've talked about them in your bestselling memoir, on your very successful podcast. And I hope that you're going to share them with us today.

We're also very lucky to be joined by gut health expert, Professor Tim Spector. Tim's going to talk to us about the power of the gut microbiome as a tool for change that you can still use even as you get older. I'd like to start right at the beginning, Rich. Today, you're an ultra-endurance athlete on a fully plant-based diet, but you made this big pivot, I think, around the time you were 40. Could you tell us what your life was like before that?

To answer that question, I think we have to cast the gaze backwards a little bit. So leading up to that, throughout my 20s, I had a struggle with drugs and alcohol that really took me to some pretty dark places. And I was able to get sober at 31. I went to treatment for 100 days.

which is a long time to be in sort of voluntarily incarcerated in what's kind of a mental institution for the temporarily insane. But that really changed my life and provided me with a new set of tools around how to like organize my decision-making and my actions.

And when I emerged from that experience, building a foundation of sobriety was like my number one priority. And I went all in on my recovery and over the next nine or so years was very focused on that. But at the same time,

I was also very intent upon reestablishing myself as a sort of respectable human being who could show up on time and be relied upon and the like and rebuild my career as a result. And during that period of time, I really overlooked my health and wellbeing because I was so focused on that one thing. And it's only in retrospect when I look back on it that I realized the extent to which

my relationship with food and lifestyle habits was still very alcoholic. Like I was using food to medicate my emotional state.

Shortly before I turned 40, I was about 50 pounds overweight. So I wasn't like obese, but I was quite sedentary. I'd been an athlete in college. I swam for Stanford in the late 1980s at a pretty high level, but really hadn't taken care of myself in quite some time. And I had an incident walking up the staircase to my bedroom where I

I had to like take a break halfway up. Like I was literally winded by the exertion of just, you know, walking up a simple flight of stairs and I had some tightness in my chest

And it was a scary moment. Heart disease runs in my family. My grandfather, who had also been a standout swimmer, had died young of a heart attack. And so heart disease was something that my mother was always telling me, you gotta be careful with your heart. And everything kind of snapped into focus as a result of that experience. And I realized that

not only did I need to make some pretty significant changes in how I was living, like I actually wanted to, like I was blessed with like a level of willingness to actually take action on that. And I think the reason that I bring up the sobriety aspect of my story

is because I'd had that history, like I'd had that bottoming out moment where I made a decision, acted on it and made a change that changed my life dramatically. And I felt the same energy. I was like, I think I'm having another one of those experiences. And what I learned about that prior experience was that you need to take action quickly because these, it's sort of a sliding doors moment. Like if you don't act upon it with some level of urgency,

whatever willingness you're experiencing tends to fade pretty quickly. And I thought, I kind of need like detox for my lifestyle. Like I need to kind of recreate that treatment center kind of experience, but for like food and lifestyle habits. And so that set in motion a series of experiments with food and diet and fitness that kind of

catalyzed this journey that I've been on that took me from there to here. And Rich, can you tell me a bit about, I guess, what your diet looked like before you were climbing up those stairs? And then tell me, like, what did you change? Maybe, you know, over the next, I don't know whether this was a instantaneous or this was the next year, what did it look like, you know, by the end of the year?

I was on what you would call the window diet. Do you know what the window diet is? Tell me about the window diet. The window diet is when you drive up to a fine dining establishment, you roll the window down and they hand you food into your car. That was the diet that I was on. So a lot of fast food, a lot of late night takeout in the law firm in which I was working as a lawyer.

Pizza Hut, Domino's, McDonald's, Jack in the Box, cheeseburgers, fries, you name it. You tried them all. I tried them all. Yeah, yeah, yeah. A lot of greasy food. So it was a big shift.

to actually go fully plant-based. And I did it almost as an experiment to prove to myself that it wouldn't work so I could make peace with the fact that I just felt the way that I felt and this is the way I'm supposed to feel and was not expecting the sort of dramatic shift in how I felt. But I tried a bunch of stuff. You know, I dabbled in paleo. I tried vegetarian. Like, I sort of checked a bunch of boxes. And the one thing that

I hadn't done because I was reluctant to do it was to go entirely plant-based because it sounded hard. It was like, who wants to do that? Like it just sounded difficult and I couldn't imagine how I could ever be full or sated with anything that I was eating. So I did it kind of as a challenge again, to like prove that it wouldn't work 'cause I really didn't want it to work. That's the truth.

So I was as surprised as anyone when it actually seemed to resuscitate me. If you're going to describe the key components of that diet, because I think it's sort of quite powerful, like describing about this shift so fast, what was the... It was eating plant foods as close to their natural state as possible. So limiting exposure to processed foods, trying to reduce the oil intake and just grazing on as many...

varieties of plant foods as possible, home-cooked and nominally limited processing. And it wasn't raw particularly? No, I didn't go... I never went totally raw. I ate a lot of raw foods, started doing...

A lot of smoothies, the base of which was always like dark leafy greens, but keeping it pretty simple, like a lot of legumes, a lot of beans, a lot of quinoa and variety, I think, making sure that I was getting a lot of variety on the plate. And Tim, you're listening to this. You're a medical doctor. I think a lot of people...

relate to this story, right? Like this is a classic story of someone, you know, anywhere in the Western world with the modern diet. You're obviously layering onto that also this story about alcohol and stress, it sounds like, with the job that you're describing. You know, what are the implications for your health? And is it really shocking that Rich would already be feeling that sort of health impact, you know, at the age of 40?

Well, sadly, it's not that unusual. And many people in the US, UK, on really high ultra-processed food diets are feeling sick and long don't realize it until they are able to change to something else and realize that's not normal.

They were in this state where the food is basically, as you're describing, driving a lot of mental health issues as well and depriving you of energy and sucking the life bit out of you.

And it's only when you make that switch that you realize the problems that we were in. And this comes from a level where the majority of the foods you're eating are these artificial foods rather than real foods. And you're not really getting the whole plants at all in any way. If you are eating plants, they're highly refined and lack any of the goodness in them. So it's not that unusual and unusual.

This is sadly why, you know, our gut health is in such a poor state as well. So that these foods in these states, you do see in people in their 30s and 40s who have appalling gut health because of their diets and their state. And this has effects on the whole body, not just the gut. And that's really what we're just starting to understand. I actually wanted to pick up on that because I was really struck by how much you were talking about

sort of mental health and energy within this story. How rapidly did you see this shift? And I'm particularly interested because it's something that I think we haven't tended to associate with diet in the same way that we might understand that it affects our risk of a heart attack or something. Sure. It was pretty rapid. Like I said, within seven to 10 days, I did feel like this

resurgence, the spike in my energy levels. But at the same time, kind of hand in hand with that, there was a hopefulness that I was starting to experience. I was used to eating a midday meal and being so tired, feeling like I had to take a nap and just kind of being checked out of my life. And so to suddenly be able to eat without that food coma that I was so acclimated around, almost like

gave me more hours in the day and my sleep improved. And when your sleep improves, your stress levels go down, you're able to kind of navigate tricky conflict-oriented situations a little more gracefully. And of course, your cognition and problem solving is better. So, there was really no area of my life that was untouched. And yes, of course, we are

we are holistic animals. Like we're not separated from the environment and our mental health and what's going on in our brain obviously impacts the entire body. And my experience was,

was pretty much 360 across the board. Like so many things improved as a result of that. And that gave me the enthusiasm to just say like, oh, this doesn't need to be an experiment. Like how can I make this sustainable so that I can continue to learn about how to do this properly and make it work for my life? Because I want to feel this way all the time. When was the last time you listened to your gut?

There's a lot of misleading health advice out there, and a lot of what we're told about food is wrong. It's time we listened to what's right. Zoe scientists are gut health experts. We have one of the world's largest microbiome databases and most scientifically advanced at-home gut health tests. This lets us provide personalized nutrition insights and advice you can't get anywhere else.

Listening to your gut starts with an at-home test kit that includes a metabolic fitness test to help you understand your body's responses to food and our gut health test that helps you understand the good and bad microbes in your gut. Then Zoe's app uses your test results to create your personalized program, helping you build life-changing nutrition habits step by step.

Gut health is central for good health. So listen to your gut and give Zoe a try by becoming a member. The first step is easy. Go to Zoe.com and use the code podcast to get 10% off. As a Zoe member, you'll get a comprehensive at-home test kit and personalized nutrition program. So go to Zoe.com and get 10% off with the code podcast. Now back to the show.

One of the things we talk about at ZOE a lot is this idea that if you want to make a change for your health, there's actually got to be a lifelong change. There's not some sort of quick fix diet that you go on to make things better for a month or two and then you go back. Obviously, that pushes all this effort into how can you make something sustainable? And so I think what's striking here is you're talking not only about making this big change at this one period in time, but then you've sustained that over close to 20 years.

Did you get all the benefits literally in the first seven to 10 days? Have you learned more and changed more through this period? Sure, of course. I mean, I've been doing this for a very long time. So yeah, I iterate, I get my blood worked on. Oh, maybe too much olive oil. Maybe I shouldn't. Of course, I'm not a perfect human being. And so I've tried to continue to learn and also to figure out

how to do it when I travel and in situations where, social situations where you feel like you need to make a compromise, all of those things, like it has to work in the context of your life. But I think to your point of making it a lifetime thing,

That can sound daunting and intimidating for someone like, oh, I have to change my whole life. Like, that's sort of scary, right? And the only way I was able to do it was I didn't make plans like, oh, I'm going to do this for the rest of my life. I always try to like...

focus my energy on what the next right decision is. Like, what's the good decision that I can make in the present moment? Like, all we have is what's happening right now, right? We spend all this time, what am I gonna do when I have to go to that wedding? And I know they're gonna serve, it's like, forget about all that. Like, just try to do

the best that you can in the circumstances in which you find yourself in, and breaking it down into tiny little chunks and let the lifetime aspect of it take care of itself. And that's a lesson that I learned in recovery. I mean, the trope of like one day at a time, I think applies in this context. And so much of what I learned in recovery

has been incredibly helpful in navigating lifestyle changes like this. Why do you feel there's such a strong link between understanding how to shift from like the traditional diet that so many of us are having

to this plant-based diet, why do you feel that's so closely linked to recovery? What makes that work so? I think it's multifactorial, but I would say in my experience, I never thought I could get sober. And then when I did, that was very empowering. Like I made a huge life change that I never thought that I could. So that gave me confidence that I could make other changes in my life.

But what I learned is that literally all you have is one day of sobriety every day. Like your job is to have your head hit the pillow without taking a drink. And it's very binary. It's like you're either...

sober or you're not, like there's no gray area. And when I made this dietary change, I kind of needed a binary rule. And that's why plant-based was very helpful to me because it's sort of like, well, I just don't eat these animal products. Let's just start there, right? And my job every day is to get through the day. And at the end of the day, make sure that I sort of made the right dietary choices. And when you drill it down into just the bare essence of it and just focus on what's happening

that particular day, it makes it a lot easier. I don't worry about what's gonna happen tomorrow, we'll deal with that tomorrow. And so that's super helpful. And then also the accountability and community piece, like you don't get sober alone, you do it as a collective. And I think if you're trying to navigate any kind of lifestyle change, it's helpful to have

somebody to do it with or somebody to hold yourself accountable to. We're community animals, we're best when we're a member of a tribe.

And so don't try to do these things alone. You know, do it with someone in your family. And if you don't have that option, then find a friend or at least find somebody who can check in on you. Hey, you know, that you know that you kind of have to report to. And that's always helpful also to kind of keep you on track. And then when you like in sobriety, if you relapse.

The most important thing is making sure that you get right back to it. You can go down a shame spiral or just throw the baby out with the bathwater and say, well, that was hard. I can't do it. But I've learned like, yes, what's the next right thing? Okay, the next right thing is to make the right choice again and try to course correct as quickly as possible and learn what drove the relapse. Because I think what's under discussed in this

conversation around making diet and lifestyle changes is the emotional piece. Like on paper, we all know like we should eat more fiber and we should eat more plants and all these sorts of things. So why is it so difficult? I had to learn about

how much my emotions are caught up in the food choices that I make. And I think we unconsciously, many people unconsciously are medicating their emotions through their food choices or are unduly influenced by their social environments and make choices that are not in their best interest because they don't wanna upset anyone or draw unnecessary attention to themselves.

When I had my medical episode, my shock, my equivalent in a way, it was not as severe probably, but I tried going vegan for six weeks for the same reason. I wanted some strict rules just to say, let's change something and see what happened. So in 2011, I was doing some ski touring in the mountains high up at 11,000 feet, got a funny turn, double vision, and I ended up having a mini occlusion, like a mini stroke.

that left me with double vision for three months and high blood pressure and lots of investigations and worries about my health. And I was four years away from the time when my father had died of a heart attack. So that was my particular scare. And I was

20 pounds overweight, but otherwise thought I was quite healthy. I didn't have as bad a diet as you did because I was a doctor. I thought I knew better. In retrospect, it wasn't a good diet, but it wasn't quite as bad as yours. So it was full of low fat foods and lots of carbs, lean meat and orange juice and mueslis and things like this that really bad for my blood sugar. Anyone who wants to change, it is quite hard because you say, well,

No one's telling you how to change. And you didn't want anything gradual. You just say, I want to do something immediate. And that's probably the attraction of all these kind of diets, the keto, the carnivore, whatever. It's strict rules. It's like joining a religion. So I did give up all meat, 99% plant-based, but not the full vegan. I still had fermented dairy. I find it easy to give up meat, not so easy to give up my fermented dairy and my cheese.

And I just wondered whether what you went through with the alcohol made you feel that if you'd sort of eaten cheese, that would have been a way, the sort of easy way back in to meat and things. Did you have a feeling about that? Yeah, because I have an addictive nature, you know, and so actually dairy was much harder to let go of than meat. I'd been eating meat my whole life and I was like, I don't even know if I like this. I've just been, I've always eaten it.

But like you, dairy was difficult. Like I had cravings, but I was like, oh, your cravings are your teachers though. Like, why do I crave this? Like, well, if I crave it, perhaps there's, you know, some kind of unhealthy relationship that I have with it that I need to look at. And it took me, you know, quite a while to kind of overcome those cravings.

where they didn't kind of take up residence in my mind, but actually getting rid of the dairy was the thing that changed the way that I felt the most. Okay, that's interesting. I'm struck rich that when you made this change,

You were already entering midlife. And I think it's a time when, you know, a lot of people, including I think quite a lot of listeners feel like, you know, I'm worried it's already too late to make a change that will stick and a change that is actually really going to be able to transform my health.

I think that's definitely the way that I felt probably 10 years ago. It was like, well, isn't my entire health set by my genes? Those are fixed. And also by sort of my upbringing, you know, my first 20 years and sort of now I'm just on the path and I can't change it. I actually think when I first met Tim, it was one of those sort of light bulb moment where he sort of explained to me this whole new idea around the microbiome that I'd never heard of before. And that because it was

changeable then actually maybe I wasn't locked in as much and Tim maybe for the benefit of listeners who might be new and haven't heard this before could describe a little bit the microbiome like what it is and then this question about like to what extent is it still changeable and why does it matter for our health at the point that you're you know maybe at your 40s but then also continuing I think there'll be plenty of listeners who are in their 70s saying well like does that mean that it's too late for me

Sure. The microbiome is the word we give the community of microscopic organisms or microbes that live in our gut, mainly in the lower intestine where that's what we know about. That's where most of the action is going on. And there are trillions of these guys, about as many as there are cells in our body. And they work together. There's viruses, bacteria, archaea, fungi, and some parasites, and they're all producing chemicals. They're like chemical factories.

And the chemicals they produce interact with the rest of our body, particularly our immune system and our nervous system. So we're finding out that these chemicals they produce are absolutely key to our healthy maintenance of our normal functions. And if we focus even just on the immune system,

We know that if the immune signals are right from the microbes, our immune system is going to be really well balanced. It's going to stop us getting infections. It's going to fight disease early on. It's going to fight cancers early on. It's going to mop up some of the debris of aging and allow our body to be really efficient going forward. So this is

What we currently believe is the sort of key to why the microbiome is not just our gut or a few sporadic mechanisms in the body. It's really crucial to the whole way the whole thing functions. And it also dampens down inflammation, which is this low level of the immune system being tickled all the time.

which is very common these days. And there's the common theory about aging, accelerated aging is called inflammo aging, inflamated aging. It's been a term that's there that people who have this low-grade inflammation will age more rapidly. And that includes heart disease, dementia, arthritis,

just because the immune system is so preoccupied putting out fires all over the body that it can't really do its principal job of mopping up the debris from the cells or fighting those early cancers or keeping all the blood vessels nice and clear and open and doing all the things that the immune system is really good at. So that's the concept of why our gut microbes and aging are so closely linked and why

Studies have been going on for a while now looking at differences in age. And it's not as clear cut as we think. So many people can maintain a really healthy gut microbiome into their hundreds. Is that right? So they've done some studies in China and Italy and centenarians showing that if you look at their gut microbes, they have the same gut health as many people in their 40s or 50s.

So something about you can maintain this. But if you look at elderly populations over 75, particularly those maybe in residential homes, you see it sort of drops off a cliff. And their gut health, their diversity of gut microbes really plummets and collapses.

It's also associated with frailty increasing. And we did some studies in the twins that predated the ZOE studies showing that this clear link between gut microbiome diversity and increase in frailty. Obviously, this is still a new science. So no one's tracked 40-year-olds for 50 years down the road. So we have to make a few assumptions on the way. But it's pretty obvious that if you can maintain your gut microbes from 40 and 50 years on,

Do it right you can keep that going right up to be a hundred without any drop in your immune system and all the things that come from it and that's that's what most of the data are telling us and particularly the Latest Zoe data, you know hit this ratio of good to bad microbes We see it doesn't matter what age you are if you've got that good ratio of good to bad bugs then You know, you're you're gonna be in pretty good shape

good shape even in, you know, your ninth decade. And Tim, when you're thinking about Rich's like really dramatic change in diet, I love this from the window diet to the plant-based diet, that's definitely two quite extreme shifts. How might that have impacted his microbiome and what were the implications from that for his health? And I guess what Rich was describing to us. When we see someone shifting from a really poor diet to a really good diet,

There have been a number of small studies and population studies and some ZOE studies show you do see a really rapid change in the gut microbes. So probably you could see it, imagine, Rich, within a week if we'd tested you at the time as you transitioned from the junk food diet to the plant-based diet.

And when we get ZOE members having their personalized nutrition program, those that are adhering to it are seeing effects within a few weeks on their gut microbes. And it all fits because those same people, although it takes for us to detect it several weeks to see it, probably the changes are earlier because mood and energy in all our ZOE studies also improve within a week.

So if you ask them, you can see differences in mood and energy, whether it's just by shifting your diet or it's having something like prebiotics. You can see these changes. And the mood and energy comes first, actually, before you see the actual changes in the gut microbes, which, again, goes back to this idea of how important the gut and the brain are. And energy is the one thing that doctors don't ask about, but actually is perhaps the most important global change.

feature of how you're feeling that I think needs much more medical attention. So yeah, in summary, these things can happen really fast, particularly if you're moving from a bad place to a good place. If you are on a really good diet and you just want to incrementally do it, it would be harder to see that. And the differences would be more subtle. But anyone who's on a poor diet, really, they make that effort, they will see results very, very fast. Hi, I have a small favor to ask.

We want this podcast to reach as many people as possible as we continue our mission to improve the health of millions. And watching this show grow is what motivates the whole team at Zoe to keep up the really hard work of creating new episodes each week. So right now, if you could share a link to the show with one friend who would benefit from today's information, it would mean a great deal to me. Thank you. ♪

When is it too late, Tim? So here we're talking about making a change of 40. You're describing a really dramatic change here, right? You're saying the microbiome changes rapidly, like in a big way, and then you're saying the health outcome changes in a big way. When's it too late? There's no evidence that it's ever too late because...

what you're doing, even if you're 90 and you suddenly say, you know, I've been lucky, maybe on the window diet, but I've, and there are these people that, you know, smoke and drink and have terrible food and they're lucky they get to that. But, you know, they want to keep going. They can improve their gut microbe just as well as someone age 40 by making that change. And they will also see improvements in their mood and energy because they

We're talking about instant changes in these microbes producing chemicals. And these chemicals can instantly impact your brain and your immune system. So it's not like you've got to wait for vessels to rebuild or some major changes to structure to happen. This is what's so great about the microbiome and lifestyle is it all happens in real time.

And that's why it's so much nicer to talk about this than what I used to talk about genetics, because that really, really is slow. It's like, well, several generations on, they'll be reaping the benefits here. And could you explain a little bit this mood and the food? Because I think a lot of people listening to this, and I think they sort of understand that you can somehow improve your heart and this makes sense. But the mood thing seems...

rather magical. Does science understand what's going on? Well, we understand a little bit of it, but we're probably just scraping the surface of what these microbes can do, what the chemicals they can produce. But it basically comes from the chemicals they produce. As I said, they're chemical factories. They produce brain chemicals, for example, like serotonin, really important for brain and enjoyment and

happiness and calm they also produce things like GABA which is the equivalent of a Valium tablet and

Body can't produce much of this stuff. So most of it comes from the gut microbes so they will be producing these chemicals which then get passed over and Picked up by receptors in the brain which will change those moods Similarly the effect on the immune system. We would damp down inflammation and then the brain Suddenly senses. Oh, there's no inflammation going on here. I don't have to be in this rather depressed State thinking I'm ill

Because the brain is just like a giant program. It's predicting what's going on. It's not often it's wrong. We think the brain is always right, but actually it's just another organ in the body. And sometimes it gets these algorithms wrong. So that's what I think that would explain these changes and why a change getting rid of a terrible diet has such a

profound rapid effect on people and the brain is perhaps the first thing to pick it up because it's not getting those sickness signals from the rest of the body.

That's fascinating. Now, Rich, when you made this big change, it wasn't only diet that you changed. I think you also made some big changes around exercise. The diet set in motion the exercise though. The diet came first and that kind of resurgence of energy made me want to move my body. And it was like one step at a time, but

I started getting outdoors more. I pulled an old pair of running shoes out of the closet. My wife bought me a bike for my birthday and it was all very casual, but I lost weight very quickly and was able to

restore some level of fitness also very quickly. And it was like the lights came on, like I had forgotten as a lifelong athlete how much I enjoyed this. And so with that, there was also kind of a recapturing of joy that I used to experience that I was reconnecting with. And then that led to a newfound kind of sense of possibility because you

had sort of derailed my competitive swimming career, I suppose I felt like I was not fully expressed as an athlete. And I think 40 also, you're like, that's why all these guys do Ironmans at 40. And there's a little bit of that too, a little bit of midlife, you're kind of taking inventory of your life.

And so that's what kind of led me towards tackling some challenges and realized not only that I had an aptitude for this, but that I really enjoyed it and ended up going on to do things I never thought I was capable of. So to your question of, is it too late? Like, I'm not a scientist, I'm a lay person, all I have is my experience, but I can tell you that

these changes that I made at 40, I was convinced that I was just sort of sliding into middle age. And instead, I kind of revolutionized how I was living to such an extent that it changed my entire life. And with it, my perception of life

like latent potential. And I've become convinced that we're all kind of tiptoeing above these reservoirs of potential that we don't give ourselves credit for having let alone

Are we encouraged to kind of tap into them? And so I don't think it's too late to Tim's point, like the body is incredibly resilient. And if you can shift a gear and start to treat it better, the body will kind of respond in kind and treat you with kindness as well.

And Rich, I want to paint a little bit of a picture for the audience. Some of them people will be listening on audio, so they won't see what a fantastic specimen of manhood you are sitting in front of me. But also I think no idea about like, what does an ultra endurance athlete mean? What is maybe the craziest thing?

right now that you feel that you have achieved closest change? I've done a couple of crazy things. I've done double Ironman distance races. If you know what an Ironman is, you swim 2.4 miles and then you ride your bike 112 miles and then you run a marathon. Well, I've done double of that. All at the same time? Yeah, basically. I'm just checking, like a year later. Well, that's sort of a stage race. But probably the craziest thing that I've done that people know me for is

doing five Ironmans on five Hawaiian islands consecutively, which ended up taking like six and a half days or something like that. So back to back to back to back, literally just doing Ironmans for like a week essentially. And I say that as somebody who, I promise you, like I'm not

somebody who's gifted with some kind of extreme athletic talent. I worked very hard to achieve those goals, but they are all a product of changing my diet and prioritizing my lifestyle habits. And I think

I'm not here to tell anyone that they should be an ultra endurance athlete. I'm here to merely say that you probably have more inside of you than you realized. And when you kind of shift that lens and start to really think about how you're caring for yourself, these things tend to suddenly become more expressed in your life.

I think it's an amazing story. I could also see that maybe there is this alternate outlook for some of this sort of obsessive behavior that you described out before. Yeah, there's a little white dusting of alcoholic behavior on top of that. This feels like a healthy way for this to... I am prone to extremes, but that's what got me interested in a plant-based diet to begin with, right? Like dancing around the outer edges of what's possible. Now,

Now, Rich, I have an investor who's going to be listening to this podcast right now, and he is very serious about his exercise. He exercises a lot every day, and he does some of the sort of activities you're talking about.

And he insists on eating red meat every day to get enough protein to perform. And since I've got this opportunity, because he doesn't listen to anything I say, or Tim doesn't really convince him, but you've done a lot more Ironmans than either of us, infinitely more than either of us. Is there anything you'd like to say to him?

Well, the first thing I would say is it's not for me to tell him what his diet should or shouldn't be. So, I'm not that person. I'm also not a scientist or a medical professional. All I can do is share, once again, like my experience. And my experience was that I was able to do things I didn't think possible without any animal products. And I went way beyond what I had even imagined for myself.

And my experiences along the way of that journey was, and this is somebody who, I was a lifelong athlete. I was a competitive swimmer at a very high level at Stanford and I was eating lots of meat and whatever. I discovered that in my 40s, I actually was recovering better in between my workouts. And that's where you make the gains. It's not the training where you get stronger. It's like the periods in between when your body is repairing itself.

And my experience was that I was able to kind of shrink the period of time necessary to make those repairs, which allowed me over time to go further, train harder, push myself a little bit harder the next time. And over an extended period of time, I think I was able to realize outsized gains as a result. So...

My experience is that you don't need to eat red meat in order to be a competitive athlete at the peak of your powers. And I'm not alone in that perspective. There's plenty of elite plant-based athletes out there. And so I would suggest to him to hold his ideas loosely and maybe look into some other examples that are similar to my own and perhaps even

Tune into our mutual friend Simon Hill's podcast, The Proof, where he talks about this subject matter at length as a scientist. And Tim, are you saying that people...

who want to be really healthy need to give up meat and animal products in the way that Rich has talked about? No, I'm not saying exactly that. And our studies, and we've just done a huge microbiome study of 30,000 people, including vegans, vegetarians, carnivores, omnivores, mainly plant-based people like me. And

Conclusions are similar to earlier smaller studies that gut health measured by the sort of the ZOE score, good to bad ratio, is correlated with the number of plants you're eating, not whether you are labeled as a vegan, a vegetarian, or a meat eater. But it is much easier to...

to get more plants in your plate if it isn't blocked with a big steak or it isn't or a big bit of fish. You're saying it's not so much about what you're taking off the plate as much as it is what you're putting on the plate. Correct. I'd like to come back just for a minute to the exercise point that we're talking about and almost tie it back to the microbiome because I think

We've done a lot of podcasts that have talked about exercise, and I've yet to meet a scientist who doesn't tell me, like, exercise is really good for your health. So that feels like it's pretty uncontroversial. And, Rich, you're describing the fact that you first did diet, then you layered exercise on top. Tim, you talked a lot about the impact of diet on the microbiome. Does the exercise also have an effect on the microbiome? Probably, but it's not nearly as clear-cut. The studies just haven't been as good. They've done lots of studies...

From elite athletes to sedentary individuals and trying to work out whether the more training you do, the better your gut microbes. It hasn't been shown conclusively to be true. And certainly they don't look to elite athletes and they don't find any difference in their gut microbes compared to amateurs or anything else. There's been a few mouse studies, but I'm always a bit skeptical about extrapolating from mice to humans for this sort of

So my guess is, although I think we still need more science, that exercise has some benefits to the gut microbiome, but if they are there, they're proportionally much less than diet. So I don't think people that say, I'm not worried about my diet, I'm going to the gym five times a week, I'm okay, Jack. That's not going to work, is my view. And I think we would have seen a big effect on

on exercise by now if it would have come out of these studies and we're just not doing it. People are desperately trying to find it because you're right, every doctor will tell you exercise is good for you and I'm saying that as well and I exercise but I don't think it's working the same mechanisms and it's certainly for gut health. I don't know how you feel. I mean, if you'd had a magic pill that allowed you to exercise, do you think you'd be in the same place?

There's that adage that you can't out-exercise a bad diet. You can't out-run a bad diet. Any kind of very enthusiastic exerciser is sort of quietly telling themselves that that doesn't apply to them.

And it can be used as a way to kind of have a healthy appetite and enjoy foods that maybe you couldn't get away with if you weren't exercising. So in that context, exercise can work at cross purposes with everything that you're sharing. If repairing or really caring for your microbiome

is something that we should prioritize, then we have to be careful about the stories we tell ourselves about exercise giving us permission to kind of indulge on food. So I think that is something that I just feel like is important to flag. But I think to the point of like us being holistic where the brain and the body are all connected,

when you exercise, you feel better. And when you feel better, you have a sunnier disposition and suddenly you have a deeper sense of how you're caring for yourself. Like if you're exercising, that is an act of self-love and self-care that then kind of leads to better habits in other areas of your life. So I think there's a compounding effect. But my mental health is very much dependent upon exercise.

you know, my exercise routine. And when I'm not exercising consistently, like I don't feel as good. And when I don't feel as good, then it's easier to slough off on healthy habits. So there's a sort of positive reinforcement between the two. Yeah, there's a reinforcement loop, I think. Do you know someone wanting to make positive changes to their health? Maybe they talk about it, but struggle to stay motivated. Why not share this episode with them right now?

Inspire them with Rich's story and empower them with Tim's expert advice. I'm sure they'll thank you. We definitely established that the microbiome is this very powerful tool to transform your health. And Tim, I love this idea that you could even be 90 and you can sort of improve it, which is brilliantly positive.

I'd love to now hear some actionable tips for showing up for this change consistently. And Rich, I know you've already touched a little bit in parts already, but I'd love to talk about how do you find the motivation to start a change and how do you find the motivation to stick to a long-term health change? I think the first thing I would say to that is to kind of challenge yourself.

the presumption here, which is that you need motivation in order to take action. Like, how do I find the motivation? You mentioned willpower earlier. Like, how do I find the willpower to like do all these things that you're telling me to do? And I think...

That assumption that you need motivation or willpower and you're kind of sitting around waiting for it is something that keeps people paralyzed in bad habits. And I have a mantra that I use that I think is very helpful. And again, it's something I learned in recovery and it's,

It goes like this, mood follows action. So rather than waiting until you're struck with inspiration, what is the thing that you can do right now? And the mood, i.e. the motivation, is a product of taking the action. And this is something that's validated in neuroscience. Behavior first, thoughts, feelings, and emotions follow. So it's about kind of

reversing that equation in your mind and breaking down again, everything into tiny actionable items. So there's a wonderful book called "Atomic Habits" that you've probably heard of by James Clear. And he always says,

habits are the compound interest of self-improvement. So you always default to your habits. And if you wanna make a habit change, break it down into its tiniest sort of elements. And so when you think of,

Oh my God, I have to like change my diet for the rest of my life. It's all very daunting. And like I said earlier, intimidating. So I'm always encouraging people to start with very easy lifts, like lower the ceiling on your expectations, broaden your timeline or forget about a timeline altogether. And just take one tiny little thing, like maybe...

"Tim, you can get rid of the fermented dairy in your fridge and replace it with something else that might be a little bit healthier." And that's all you're doing. Just go into your pantry and like, "You know what? All these chips in here, I'm just gonna take them out of the house."

Maybe you didn't, that was all you did that day, but you, you like chalked up an easy win. So I think it's about like assembling a lot of easy wins. And when you just kind of like focus on tiny little things that you can master, that does have a compounding effect. And when you, when you,

teach yourself that you can do that, like, and you make that one little change, you're like, oh, I did that. And now that's really not an issue for me anymore. What else can I do? Like, let's move on to the next thing. And you just kind of build on these things

I believe that that is really how you make change. So it's about the tiny little daily habits that you're almost reflexively or unconsciously indulging every single day and drawing attention to those rather than making dramatic wide sweeping statements like, "Yes, I went plant..." All that kind of stuff. But I don't think that's how it really works for most people. And I think

kind of just gradually leaning into this as a process rather than a result driven by this day, I have to weigh this much. I think you're in better stead to then adopt habits with staying power 'cause this is really all about sustainability.

having it all kind of work in the construct of our, you know, we all have busy lives and we're all, you know, kind of doing lots of different things. So how can you create an environment that's conducive to making the healthy choices and chalk up those little wins with small little habits that you can build upon? I'd love to just follow up on this thing about how you describe exercise actually providing you with this sort of

support for your mood that it sounds to me is like helping to enable all the things that you're describing. So if you were to give advice for someone who's trying to, let's assume they're not like a super sophisticated athlete, but maybe they're like, oh, I'd never even thought that I could use exercise in some way to sort of support my mood to achieve change.

What would you say to them? To find a movement practice that you enjoy. So what's the best exercise? What should I be doing? Well, what's the thing that you like doing? And if you enjoy it, you're more likely to kind of invest yourself in it and make it kind of a sustainable habit in your life.

So think about what it is that you actually enjoy and find a way to incorporate that into your life in a way that's not disruptive, overly disruptive to your daily schedule so you won't abandon it. You know, like on February 1st, you're like, okay, I can't do this anymore. And find people to do it with, like make it a community-oriented sort of thing so that you're, you know, kind of sating yourself with human connection at the same time that you're moving your body. And

Set reasonable goals or don't set any goals at all. Just do it for the sake of doing it. And that could be a walk in the woods or, you know, walking the dog around the block. It doesn't have to be, you know, any kind of big daunting thing. But I think it's important for everybody to understand that in terms of

health span extension and longevity, there is no more powerful lever than exercise. It's never too late to start. And it doesn't mean, again, that you need to go and be an ultra endurance athlete. It just simply means that you have to find a way to exert yourself. And I think if you find something that brings you joy in the process of doing it, you're more likely to stick with it. I think it's beautiful.

Tim, final simple question for you. What is one type of food that someone could add to their diet tomorrow that could improve their gut health? Fermented food would be the obvious one for me. A lot of people don't have much in the way of fermented foods, fermented vegetables, you know, the kimchi, the sauerkraut. These are an amazing source of microbes and will help your inflammation, which will, should in theory, you know,

Let's reduce the speed of aging amazing

Rich, Tim, I'd like to try and do a quick summary. We covered a lot of stuff in this episode. So definitely let me know if I've missed anything. I'm going to try and pull it together. So my biggest takeaway was that Rich was on the window diet, which I'd never heard of before, which meant that all your food came in through the window of the car and then into your mouth. And this is a pretty terrible diet to be on. I also really struck this idea about medicating your emotions with your food choices, that this food becomes this thing that's really linked to how you've

you feel and it's giving you this sort of short-term boost, which I think we can all identify with. But then you're describing just how bad an impact it was having on you. I think my other key message is that I took away is it's like never too late to make a change. And we're talking here about making this change in midlife.

But I think I'm also hearing from both of you that it's almost never too late to make a change that can be profound. And a lot of this comes from this realization that our microbiome is so important in our health, and unlike our genes, it's not fixed.

And I think Tim was describing some of the science, Rich, to go with your experience of how like your mood could actually change in like seven to 10 days because of the way these chemicals from this bacteria was changing. And that then it gave you sort of energy, it affected your sleep, and that then that itself sort of gave you the positivity to do more exercise, which then sort of became this reinforcing loop.

We talked about meat and I definitely took away from you, Rich, that you can do the sorts of things that you're doing without eating meat. That on the other hand, what I have to do, it's not like you have to give up meat. The point is that once you really reduce the meat in your diet, suddenly you're creating all this space to eat all of these plants that are having the

the positive side. And then we talked about how you think about willpower coming from a lot of your own experience through recovery, which I'd never heard before. And that a lot of the things that I take them for granted, you're like, well, actually, I think that's wrong. So for example, take it one day at a time. Don't think about making a permanent life change. Actually, just say, I've got each day to do this.

That rather than saying, I need to wait till I have enough willpower to do it, actually, it's the complete reverse. Your mood follows action. So do something. And actually, in a sense, if I understood rightly, like your mood will improve and that will give you more of this willpower to go for it. And that if you relapse, then like,

start back on the course. And so it's just very different from this sort of like New Year's Day, make this big, crazy plan and then sort of give up. And it's okay to start with an easy win, I think you said. So again, it can be sort of incremental step-by-step because you're building on this.

And then finally, my takeaway was one of the things that's interesting about exercise is not just about long-term health. Actually, it can provide a lot of mental support for you to actually be doing these other positive things with your life. And so you're describing that actually exercise helps to support your mental health, that helps to support your diet. And maybe to wrap up,

You were saying like, if you want to get into exercise, find a movement practice that you enjoy. So it's for something that you are actually going to enjoy doing it, that you can incorporate into your life. You're not going to give up

after a month. It's not disruptive. Find people to do it with. And then finally, I love this idea. You said set reasonable goals or no goals at all. And all of this just increases your chances of success. Did I manage to? That was great. Will you now come to my podcast and do a synopsis summary at the end of every conversation? Because that was fantastic.

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