cover of episode INTERVIEW: The Evolution of Diabetes Treatment with Gary Taubes

INTERVIEW: The Evolution of Diabetes Treatment with Gary Taubes

2024/6/5
logo of podcast The Doctor's Farmacy with Mark Hyman, M.D.

The Doctor's Farmacy with Mark Hyman, M.D.

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Mark Hyman: 本期节目讨论了糖尿病治疗的演变,以及现有治疗方法的局限性。我们探讨了酮类饮食的作用、奥泽帕利西等药物的影响,以及重新评估糖尿病管理方法的必要性。我们需要挑战现有假设,认识到代谢功能紊乱是许多慢性疾病的根本原因,并寻找更有效的治疗方法。 Gary Taubes: 本书《重新思考糖尿病》探讨了糖尿病治疗史上的错误,以及这些错误如何导致了糖尿病的流行。我们对糖尿病的理解存在偏差,例如,大多数2型糖尿病患者并非胰岛素缺乏,而是胰岛素过量。传统的治疗方法,如积极控制血糖,反而增加了死亡率和心脏病发作率。我们需要重新评估证据,挑战既有假设,并探索更有效的治疗方法,例如低碳水化合物高脂肪饮食。 Gary Taubes: 本书详细回顾了糖尿病治疗的历史,从18世纪的动物饮食到20世纪的胰岛素治疗,再到如今的GLP-1激动剂。我们发现,早期的高脂肪低碳水化合物饮食疗法对糖尿病患者有效,但胰岛素的发现改变了治疗方法,导致了低血糖症和体重增加等问题。口服降糖药和胰岛素治疗的疗效并不比单纯饮食疗法更好,反而增加了心脏病和中风的风险。我们需要认识到,并非所有卡路里都相同,不同营养素对人体激素反应和代谢反应的影响不同。脂肪储存受多种因素调控,并非仅仅取决于摄入量和运动量。胰岛素抑制脂肪分解,促进脂肪积累。我们需要挑战既有的假设,重新思考糖尿病的治疗方法。

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Approximately 1.2 million Americans are diagnosed with diabetes each year​. Understanding the complex nature of this disease is crucial to tackling this widespread health issue. Award-winning science and health journalist Gary Taubes joins me to delve into the history of diabetes and modern treatment options. Together, we explore the use of ketogenic diets, the impact of drugs like Ozempic, and the need to reassess our approach to diabetes management. 

In this episode, we discuss:

  • The evolution of diabetes treatment

  • Assumptions about diabetes and the influence of dietary choices

  • The role of calorie intake and exercise in diabetes management

  • The limitations of current drugs used to treat diabetes

  • Clinical trials and their impact on our understanding of diet and health

  • The choice between drug therapy and dietary changes in managing diabetes

Join us to discover how bias and ingrained beliefs can obstruct progress in understanding how to treat this chronic illness.

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