In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness. We discuss:
- His background and early work with coronaviruses [2:45];
- The coronavirus family—various types, common traits, and scientific understanding [9:00];
- The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45];
- Insights from the 2002 SARS outbreak [28:30];
- Insights from the 2012 MERS outbreak [35:00];
- Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00];
- COVID-19 survivor potential for long-term damage [53:30];
- Using the current pandemic for lessons on future preparedness [57:00];
- Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00];
- Prevention and treatment strategies for COVID-19 and future diseases [1:22:30];
- Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30];
- Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and
- More.
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