cover of episode As Marijuana’s Popularity Grows, So Do Its Harms

As Marijuana’s Popularity Grows, So Do Its Harms

2024/10/22
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Megan Twohey: 本人作为消费者,亲身经历了近年来美国大麻市场因合法化和商业化而发生的巨大变化。合法化初衷是用于医疗,但娱乐性大麻市场已超越医疗市场,监管不足。大麻产业更关注生产高浓度产品,而非治疗性产品,且缺乏科学研究支持。大麻使用率持续上升,尤其每日或几乎每日使用的人数显著增加,超过了酒精使用人数。大麻使用障碍(CUD)患病率很高,约有1800万美国人患有某种程度的大麻使用障碍,其中约300万人被认为成瘾。年轻人(18-25岁)中,大麻每日或几乎每日使用率高,且大麻使用障碍患病率极高。大麻素呕吐综合征(CHS)是一种与长期大麻使用相关的严重疾病,会导致剧烈恶心、呕吐和脱水等症状。CHS在急诊室中越来越常见,估计多达30%的重度大麻使用者会出现CHS症状。大麻与精神病发作之间存在关联,即使是初次使用或没有其他风险因素的人也可能出现精神病症状。大麻会影响大脑发育,尤其是在青春期,并可能增加患慢性精神疾病的风险。公众对大麻的认知没有跟上大麻产业的快速变化和使用方式的转变,导致对大麻潜在危害的认识不足。大多数受访医生支持大麻合法化,但认为目前的监管存在缺陷,需要改进监管、加强消费者保护并提供更多信息。 Rachel Abrams: 作为一名记者,我与Megan Twohey讨论了大麻合法化带来的益处与危害,并对大麻成瘾、大麻素呕吐综合征(CHS)以及大麻与精神疾病之间的关系进行了深入探讨。我们还讨论了公众对大麻的认知与实际情况之间的差距,以及改进监管、加强消费者保护和提供更多信息的必要性。

Deep Dive

Key Insights

Why are some marijuana users experiencing serious health issues?

Increased potency and frequency of use, lack of regulation, and inadequate health tracking contribute to unexpected harms.

What is cannabinoid hyperemesis syndrome (CHS)?

A condition causing severe nausea and vomiting in chronic marijuana users, often relieved by hot water.

How does marijuana use affect young people?

It can lead to higher rates of cannabis use disorder and potential mental health issues, especially during critical brain development.

What are the potential mental health risks of marijuana use?

Temporary psychotic episodes, increased risk of chronic psychotic disorders like schizophrenia, and impact on brain development.

Why is there skepticism about marijuana's harms?

Public understanding hasn't kept pace with the drug's transformation and commercialization, leading to misconceptions about its safety.

What does the majority of doctors and harmed users advocate for?

Better oversight, protections, and information about marijuana's potential risks to ensure safer use.

Chapters
Driven by legalization and commercialization, the marijuana industry in the US has rapidly grown, leading to a surge in the availability of high-potency products. This transformation has outpaced scientific research and regulatory oversight, creating a knowledge gap regarding the potential health consequences of this new era of marijuana use.
  • Legalization of marijuana in the US has led to a booming $33 billion industry.
  • The industry mainly focuses on high-potency products, neglecting therapeutic applications.
  • Research on marijuana's effects is limited due to its federal illegality and restrictive drug classification.
  • Hospital and healthcare data on marijuana's effects are inadequate.
  • State-level regulations on marijuana lack consistency and effective health outcome tracking.

Shownotes Transcript

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Support for this podcast comes from Avangrid. This is definitely a blue-collar community, and I'm kind of a blue-collar guy. Rick Sealscott didn't see himself as a farmer, but wasn't about to sell his grandparents' Ohio farm. And Avangrid Wind Farm pays millions to the community and landowners like him each year. Farming's up and down, but the wind turbines give us steady income. We're holding on to the farm, and we're making money. And I would absolutely do it again.

Discover where energy meets humanity at ovengrid.com. From The New York Times, I'm Rachel Abrams, and this is The Daily. This election day, recreational marijuana could become legal across more than half of the United States.

But as more Americans consume more potent forms of the drug more often, a Times investigation has revealed that some of the heaviest users are experiencing serious and unexpected harms to their health. Today, I spoke with my colleague, investigative reporter Megan Toohey, about what she found. It's Tuesday, October 22nd.

Hi, Megan. Hey, Rachel. Thank you for being here. So, Megan, today we're going to talk about something that a lot of people, myself included, have at least a glancing familiarity with, and that's marijuana. So tell me, first of all, how did you come to this story? Well, full disclosure, I am one of those people who has some familiarity with marijuana. I have dabbled in it on and off, stretching back to the 1990s. And I think it's

And so I, as a consumer, have also been among those who have

noticed the drastic transformation of marijuana in this country in recent years as legalization spread and the commercialized legal industry sprung up and began offering products. And so, you know, here in New York, a couple years ago, when we implemented the legalization of recreational marijuana, there was sort of all of a sudden dispensary selling products on nearly $1

Like every corner. Everywhere. Everywhere. And so I was one of the people who started going into the dispensaries and immediately noticed that the products I was seeing there were very different from some of the products I had consumed. You know, there were pre-rolled joints and gummies and these like almost pure concentrates of THC, which is...

the intoxicating component of marijuana. And so I could see for the first time that there was a huge range and that there were products that had like really, really high levels of THC. And so I would purchase these little containers of gummies that contain THC

five milligrams of THC, which is on the very low end. But when I would go home and take little bites of them, in my experience, they were actually quite strong and were being framed as completely almost innocuous.

You know, I have to tell you, I've also had kind of a hard time navigating this market and these shops that are for recreational use. But you can also go in and you can say something like, I have a headache or I have trouble sleeping. And somebody who is not a doctor, is not a pharmacist, is suddenly recommending a product to you to help you with your health issue. Well, I think you make a really good point, Rachel, which is that...

Legalization of marijuana began as the legalization of medical marijuana in this country. I mean, the first states to legalize did that for the purposes of people being able to use it for health reasons. But what we have seen in the last 10 years is that what began as a medical marijuana market has been superseded by a recreational marijuana market.

And, you know, the promise of legalization was that it was going to make marijuana more safe, that with legalization you'd have regulation and oversight and more protection of consumers. But there's now a $33 billion industry that sprung up to deliver these products in this newly legal market. And the products that they're delivering are unlawful.

at potency levels that were almost unimaginable a generation ago. And I knew from not just my own personal experience of interfacing with the commercial market, but also from people in my life and in my various, like, orbits, I was hearing about people who were actually struggling with marijuana. And those folks and their families were

had a lot of confusion. Like, isn't this supposed to be this totally safe and totally natural and now totally legal drug? And it just felt like there was a real vacuum of information. So what did you do just to start trying to understand this world that's obviously confusing a lot of people? So with that kind of initial interest, I just started to make some phone calls and

One of the first people I called was a longtime medical marijuana researcher who helped develop a couple of the only pharmaceutical drugs that have cannabis components that have received regulatory approval.

Interestingly enough, one of the first things he said to me was, oh, my God, good luck reporting into this. It's like a total jungle. I've been in this world for decades, and even I have a hard time following exactly what's going on because so much has been shifting so fast.

And so that was a little scary to hear, but also intriguing. And one of the things that he said was that he had major concerns with the way that legalization and commercialization of marijuana was playing out here in the United States. He said that scientists and researchers—

And doctors like himself were on the sidelines that they weren't being consulted as this was rolling out. And that the industry that had sprung up, this $33 billion industry, was also not focused on the therapeutic products of the drug, but instead had basically ended up in a race to produce the most potent products, the most intoxicating products possible.

And what I next realized was that there was a real dearth of research, of scientific research into the effects of marijuana. And that's in part because while marijuana is now legal in about half the states,

It has remained illegal at the federal level. And it's also in this highly restrictive category of drug, which makes it really challenging for people to do research on it. Also, the hospital and other health care data on the effects of marijuana was really inadequate.

And the patchwork of state laws that had sprung up to govern this was not equipped to do any meaningful tracking of the health outcomes. And so after a while, I realized that if we really wanted to have a deeper understanding of how this drug was affecting consumers across the country, we were going to have to figure out ways to gather that information ourselves. ♪

I was lucky enough to, at this point, be joined by two of my colleagues on the investigations team, Danielle Ivory and Carson Kessler. And one of the first things that we sought to tackle was this

on drug use in this country. Every year, the government does a population survey that asks Americans about their use of drugs and how frequently they use it and seeks to measure the effect on their lives.

And mostly what people have focused on are opioids because historically those drugs have killed the most people and done the most harm. So what this survey has shown on marijuana use hasn't received a ton of attention. It's sort of been flying under the radar.

But we found a researcher at Columbia University who has looked at this data and looked specifically at marijuana, and we asked her to do a more detailed analysis of those responses for us. And what did that analysis find? Well, the survey has turned up some very interesting trends with regards to marijuana use in this country. It has shown that as legalization and commercialization of marijuana has taken off and accelerated,

that marijuana use has been going up steadily among people 18 and over. And it's not just that more people are consuming here and there. There are pretty sharp rising rates of people who are using it on a daily or near-daily basis. And this survey showed that in 2022, in fact, for the very first time, more people said that they were using marijuana on a daily or near-daily basis than said they were using alcohol.

But not only are people using marijuana at higher rates than ever before, more people are reporting that their marijuana use is having a negative impact on their lives. And this is more broadly known as cannabis use disorder. There's 11 specific criteria that are used to measure whether or not somebody is having like a problematic use of a drug. And, you know, it ranges from like building up tolerance to craving the drug to not being able to stop

even if it's having negative effects on your social life or your job. And, you know, if you meet two of the criteria, then you are considered to have a mild case of cannabis use disorder. And then on the far end, if you meet six or more criteria, then you are considered to have a severe cannabis use disorder, widely seen as addiction. And what this analysis showed was that 30% of cannabis users 18 and over were

reported having some level of cannabis use disorder. That's like an estimated 18 million Americans. And other...

And of those, about 3 million people are considered addicted. I have to say, I was really surprised to hear that, that people could be addicted to marijuana. And frankly, I guess I was like a little skeptical when we were discussing and planning this episode. And it actually prompted a whole discussion here at The Daily about this, where people were saying, you know, actually, I know this one person who has an addiction problem. I know this other person who has an addiction problem. It was really, at least for me, it was really quite eye-opening.

Yeah. Listen, I think that there has long been this belief that marijuana is not addictive. And I think that that's in large part because it presents differently than, say, alcohol addiction or opioid addiction, for which withdrawal can sometimes be so severe that it can be fatal.

But in recent years, medical experts have been able to show how when our systems are basically overrun with THC, you need more and more to get the same effect. And when you stop using, you can experience anxiety, depression, and other symptoms of withdrawal. So what else did you find in your analysis of the data? We found that this problematic use of marijuana is significant.

you know, really stark among young people. Like in the 18 to 25-year-old group, 4.5 million of them use marijuana daily or near daily. And of those, 81% meet the criteria of cannabis use disorder in some way. Wow. So basically, millions of young people are using marijuana every day, and a huge percentage of them are reporting problems with it. So...

I mean, doesn't that seem like a clear warning sign? Yes, like for sure. Now, I should say the vast majority of people who use just general users of marijuana are not having problems with it. But we wanted to learn more about those who were. And when we started gathering more information, we were surprised by just how severe some of those issues could get. We'll be right back.

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Okay, so what kind of problems were chronic users reporting? Well, there were actually a couple of issues that we heard about. And to get a clearer picture of them and understand how common they were, we started crafting a bunch of surveys. And we posted them in a Facebook group where people had come together to discuss one of these severe health effects from marijuana.

And we also sent out surveys to doctors from a variety of fields across the country asking what they were seeing with their patients. And we started to see some really concerning issues again and again. Like what? Well, let me tell you about one woman we met. Hello. Hi, is this Jennifer?

Yes, it is. Hi, this is Daniela. Her name is Jennifer Macaluso. She's from Illinois. And my colleague, Danielle Ivory, spoke to her over the phone. Is this still a good time for you to talk? Yeah, this is great. All right, excellent. And in a way, Jennifer is a great example of a kind of person who started using weed post-legalization. You know, I'm 51. I used cannabis brazenly.

You know, she had smoked when she was a teen, but nothing very serious, and had actually stopped as an adult until she got a bit older. Yeah.

She got migraines. And she took a lot of medication to get them under control. Here I am popping pills every day just to function. So my doctor at the time suggested, what about medical marijuana? It had become legal in our state a few years prior. And, you know, I thought, wow, okay, yeah. You know, I'm always one for a more natural route. So she started using weed on the recommendation of her doctor.

to help with the headaches. And at first, it was phenomenal. I could, you know, take a couple of hits or take an edible, and the migraine was gone. And I thought, this is fantastic. I don't have to take all these pills anymore and all this stuff. And Jennifer found that using marijuana medically really helped her with her health problem. She was using a couple times a week, and that was enough. It solved the issue right away.

And then... About six months into it, I started getting stomach aches. She starts to experience some nausea. I started waking up nauseous every single morning. I just was dry heaving and sometimes I would vomit and it just was... And an employee at the marijuana dispensary that she used advised her to increase her marijuana use.

And eventually she was using the drug nearly every day. But the nausea actually got worse. She was sick.

She starts to get cycles of severe vomiting and stomach pain. I was pretty much bedridden. I mean, on a good day, I was just mildly nauseous. On a bad day, I was, you know, on the bathroom floor, crying my eyes out, you know, just totally desperate for help. She was often in immense pain, and it was really scary to her.

But when she sought medical attention, you know, they had no answers. They said, well, doctor after doctor could not figure out what was wrong with her. Then they started doing CAT scans and stomach tests and, I mean, blood tests and all these workups and, you know, you name it, I had it.

over the course of three years. I went to 12 different doctors. I went to including four different gastroenterologists. I went to neurologists. I went to internists. I went to functional medicine doctors. I

She gets all of these different diagnoses. At one point, she actually has her gallbladder removed. Oh, my God.

And it was really discouraging because nothing was helping. I really had some very dark days where I thought, you know, I'm going to die. Because this is it for me. I can't get out of bed, you know. And no one seems to know what to do. And, you know, this is it. ♪

Then one day... June 16th, 2022. I will remember the day. She's once again on the internet trying to find any possible cause for this pain that she's in. And, you know, way down on the Google search pages, I saw a link to the Facebook page. And she finds this Facebook group that is made up of people who are suffering from a condition called cannabinoid hyperemesis syndrome, known as CHS.

And it's the first time she has any inkling that the weed might be causing her pain. And what exactly is CHS? Well, it's really interesting, right, because marijuana is widely known for helping with nausea. But in some cases, with certain chronic users, it can actually have the opposite effect. We're talking about really severe nausea, severe vomiting, cycles of severe vomiting, in which people...

People are in so much pain that they actually use the term scrommeting because they're often screaming out in pain. It's so awful. Oh, my God. Yes. And this is a relatively new syndrome. It was first identified in 2004. And basically, it's rise, like completely tracks with the rise in legalization and commercialization and the change in these products. Yeah.

And it's still quite a mystery. They don't know why some chronic users get it and others don't. And there's also this telltale sign to the syndrome that is also not understood, and that's that hot water often relieves symptoms. So people who develop this syndrome will often spend hour after hour in really, really hot baths or showers, sometimes to the point where they burn themselves. Right.

And the cases can be really severe. It can lead to extreme dehydration, seizures, kidney failure, and even cardiac arrest. We found eight deaths linked to CHS. Wow. How common is this syndrome? It's hard to say with certainty just how many people are suffering from CHS at this point. You know, even 20 years after it was first identified, there's not a single diagnostic code for it. So there's no uniform tracking of it in the medical system.

But what we heard from our interviews and surveys of doctors is that they're seeing more and more of it. And many described it now as a common thing that is presenting in emergency departments. One doctor referred to it as a bread-and-butter diagnostic. Others said they see it every week, if not every day. And there are also researchers who have estimated that as many as

30% of heavy users, regular users of marijuana are experiencing some symptoms of the syndrome. So that would mean an estimated 6 million people. And Jennifer is one of those people, correct? What happened to her? So after finding the Facebook group and realizing what's going on. You know, I had taken my last edible at 9 o'clock that morning. And this was at 9.30 when I found the page. I said, that's it, I'm done.

She decides to quit marijuana on the spot. And that leads to a period of withdrawal that lasts for about two months.

And I just got better and better from then. And, I mean, it's been two years, and I'm fine. Wow. And after that, she's been totally fine. That is wild. I mean...

And during this period of withdrawal, she sees yet another specialist who confirms that she did indeed have CHS and actually told Jennifer that she was seeing multiple cases of the syndrome every week. You mentioned before that there were several potential marijuana-related health issues you were looking into with those surveys. What else did you find?

So another significant harm that we identified that is very concerning is the relationship between marijuana and psychosis. And one of the ways that that plays out is marijuana causing a temporary psychotic episode or symptoms, paranoia, hallucinations.

And that can happen to all different kinds of people, people of different ages, chronic users of marijuana or first-time users of marijuana, people who are otherwise at risk for experiencing psychosis or have no other risk factors at all.

And, you know, one of the people that I spoke to who had experienced this is a man named Javante Hill, who lives in Colorado and tried marijuana at the suggestion of his girlfriend.

You know, I'm not like a pot smoker. You know, I just got out of the military. Mm-hmm. You know, so zero tolerance for drugs. So as soon as we got out, I was like, well, you know, let me go ahead and try what the hype is about. Mm-hmm.

He was a recent Navy veteran with PTSD, anxiety and depression. And his girlfriend was an occasional marijuana user and told him that it could be a nice way to chill out. And it was honestly to wean off, like, you know, go from alcohol to this one because the media around we was that is a much safer alternative. You know, you don't wake up hungover.

So one night, and this was just his second time using it, he took a bong hit. And then literally after 10 minutes, I started to have almost like severe paranoia. And ended up totally paranoid and hallucinating. Slowly, but surely as the night went on, I completely lost all touch with reality.

And I replayed a lot of my time in Afghanistan. And it's almost like all my worst fears came to a forefront. And I was seeing the pictures of the devil and hell and just like literal demons I thought were like in real life. He said it was like he was in hell with devils. Oh my God. I was marching all throughout our house.

I was trying to find Eva the whole time. I had no idea where she was at. His girlfriend, Eva Zamora, who I also spoke with, was there trying to comfort him, but he didn't recognize her. Wow. And in the midst of this, their dog started fighting. And then he had gone upstairs and he came downstairs and he, um, and he had,

And he ended up getting his gun. And he looked like he was scared. But he had the gun up and he took some shots. And as soon as that happened, I ran.

and shooting and killing one of the dogs and actually shooting and injuring his girlfriend, Eva. It was very dramatic. Yeah, it was horrible. He had no idea that this was a risk or even a possibility when he tried that marijuana. Nothing like this had ever happened to him before. You know, he had no history of psychosis. He had no history of domestic violence.

After the incident, he was diagnosed with drug-induced hallucinations, and he ended up pleading guilty to animal cruelty and assault charges. And he's actually suing the dispensary chain, claiming it failed to warn him about the risk of psychosis. And that type of temporary psychosis caused by marijuana is something that doctors are

seeing across the country. In our interviews and in our surveys of doctors, they said that they were seeing more and more patients with those kind of experiences. Wow. And you said that that kind of psychosis was temporary, but are there any other longer-term mental health implications?

So marijuana can affect brain development, particularly during the critical period of adolescence, which actually goes up through age 25. And this is also the period when chronic psychotic disorders like schizophrenia typically emerge.

And there's growing evidence that marijuana use can contribute to the development of those psychotic disorders. Recent studies show that the more potent the cannabis, the more frequent the use, and the earlier the age of consuming, the greater the risk. And to be clear, this isn't like a clear-cut black-and-white cause-and-effect relationship between marijuana and chronic psychotic disorders.

One researcher that I talked to, a professor at Yale University who's paid a lot of attention to this issue, actually compared it to cigarette smoking and lung cancer. You know, not everybody who smokes cigarettes gets lung cancer. Not everybody who has lung cancer smokes cigarettes. But we know after decades that there's a strong association between the two. And as he put it, the same goes for marijuana use and these chronic psychotic disorders.

And doctors told us that they are seeing more and more of these chronic psychotic disorders in which they believe cannabis played a role. You know, Megan, we've talked about a few of these potentially awful side effects from marijuana use, like addiction, the bouts of vomiting, psychosis, and just longer-term mental health effects.

And what strikes me is that all of this stuff really runs counter to the narrative that I imagine a lot of people have about marijuana, which is that it's relatively safe. Yeah, listen, our public understanding of this drug hasn't kept pace with the transformation of it and this new commercial industry and these shifts in how people are using it.

And I know at least from many of the people who have experienced harms from marijuana, some of these harms that we've discussed, that when they tried to talk about it, they often ran into not just skepticism, but also sometimes downright hostility. Yeah, actually, you're reminding me. I noticed that when The Times posted your story on Instagram, there was this comment from the comedian Eric Andre, and he said something like, whose side are you on?

And it made me wonder how broadly you felt that sentiment, like after all this work to increase access to marijuana, were people not receptive to hearing that it might be bad for you? You know, I actually saw that comment as well, Rachel, that caught my eye. But I want to be very clear about what else we found in our reporting, which is that the majority of the doctors that we talked to support

the legalization of marijuana. Even the majority of people that we interviewed and surveyed who had been harmed by marijuana, none of them were saying, like, this is categorically a bad drug and should not be made available.

What we heard time and again is that the way that legalization and commercialization is playing out in this country is flawed, that the government and the medical system need to be doing more to track the health effects of marijuana. They need to be doing more to document that. And they need to also be communicating that to consumers, that these consumers have a right to know about the

associations with psychosis. They have a right to know about the risk of this becoming addictive. They have the right to know about CHS. You know, Jennifer Macaluso, for example, said, if I had known that CHS existed, if that had been on a warning label, I wouldn't have increased my use of the drug when I started experiencing symptoms. Right.

And so I think that the uniform message that came out of this reporting was there needs to be better oversight, there needs to be better protections, and there needs to be better information. Megan, thank you very much. Thanks for having me. We'll be right back.

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Here's what else you need to know today. I am grateful to be back here in Lebanon, but I have to admit that I am saddened to bear witness to the pain of its people and what they're experiencing. In Lebanon on Monday, a top U.S. official said that the growing conflict between Israel and Hezbollah has spun out of control. And he outlined a proposal to bring it to an end. And I want to be very, very clear. Tying Lebanon's

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Israel's recent military operations against Hezbollah, the Iranian-backed group that has launched thousands of rockets into Israel, has caused a humanitarian crisis in Lebanon that has displaced about a fifth of the country's population. Today's episode was produced by Will Reed, Alex Stern, and Olivia Nat. It was edited by Mike Benoit, with help from Mark George.

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