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Plant-Based Fiber and Metabolic Homeostasis

β-Glucan's Unique Benefits:

• Howard et al. demonstrate that only β-glucan significantly reduced body weight gain, adiposity, and improved glucose tolerance in HFD-fed mice compared to other fibers. This was linked to increased energy expenditure, potentially due to increased butyrate production.

• Medical News Today highlights β-glucan's role in improving blood sugar control, supporting the findings of the Howard et al. study.

Fiber-Specific Microbiota Shifts:

• All three sources emphasize that each fiber type uniquely alters the gut microbiota composition.

• Howard et al. observed increased Ileibacterium and Parasutterella abundance in the cecum and small intestine of β-glucan-fed mice. These bacteria are associated with weight loss and bile acid metabolism.

• Mandelli et al. shed light on the expanded functionality of a β-glucan utilization locus (PUL) in an herbivore gut bacterium (Alloprevotella sp.) compared to its human counterpart. This PUL efficiently processes different forms of β-glucans, including those with β(1,6)-linked substitutions, highlighting dietary adaptation.

Bacterial Metabolites:

• Howard et al. show that all fiber types altered cecal short-chain fatty acid (SCFA) profiles. However, only β-glucan increased butyrate concentrations, potentially contributing to increased energy expenditure and improved glucose homeostasis.

• Both Howard et al. and Mandelli et al. stress the role of specific enzymes within the β-glucan utilization pathway. Notably, Mandelli et al. characterise a unique β-glucosidase in Alloprevotella sp. that specifically targets β(1,6)-glucosyl linkages, highlighting the bacteria's adaptation to diverse β-glucan structures.

Bile Acid Metabolism:

• Howard et al. observed altered small-intestinal and portal bile acid composition with all fiber types. β-glucan and wheat dextrin increased unconjugated and decreased conjugated bile acids, potentially influencing bile acid signalling pathways like FXR and TGR5 involved in metabolic regulation.

Important Quotes:

• Howard et al.: "These findings demonstrate that β-glucan consumption is a promising dietary strategy for metabolic disease, possibly via increased energy expenditure through alterations in the gut microbiota and bacterial metabolites in mice."

• Mandelli et al.: "This gain of function [in the herbivore β-glucan utilization locus] emerges from molecular adaptations in recognition proteins and carbohydrate-active enzymes... These findings broaden the existing model for non-cellulosic β-glucans utilization by gut bacteria."

Implications and Future Research:

• β-glucan emerges as a promising dietary fiber for weight management and blood sugar control, potentially exceeding the benefits of other fibers.

• Understanding the specific bacteria and their enzymes involved in β-glucan utilization can guide the development of targeted prebiotics or dietary interventions.

• Further investigation into the interplay between fiber-induced microbiota shifts, bacterial metabolites (SCFAs and bile acids), and their influence on host metabolic pathways is crucial.

• Translating these findings from animal models to humans is essential to confirm the therapeutic potential of β-glucan and other fibers in managing metabolic disease.