The Reddit post and subsequent comments center on a user's frustration with his "friends," who set him up on a blind date as a prank. The user, a medical resident who is autistic, actually enjoyed his date with the woman and asked her out again. However, his "friends" are upset, believing they ruined the joke and are even going so far as to call the user "weird." Many commenters agree that the "friends" are in the wrong and suggest the user cut off these toxic individuals, who seem to value their own sense of humor over the feelings of others. This interaction highlights the importance of understanding and respecting neurodiversity and challenging harmful stereotypes.