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cover of episode The History of Gout, Part 1

The History of Gout, Part 1

2018/10/5
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Healio Rheuminations
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Shownotes Transcript

Do you know the etymology of the word “gout,” or how a simple microscope aided in the identification of tophi? Join me as I explore the history of this inflammatory arthritis and highlight the important scientists who shaped the modern era of gout.

  • Intro :10

  • What to expect in Part 2 :48

  • A question: Which urate-lowering therapy was made for an expressly different reason than to treat gout? 1:34

  • The first modern description of gout 1:54

  • Let’s go back to the Greeks 3:05

  • Why is it called “gout?” 3:06

  • An anecdote from medical school 4:13

  • Hippocrates’ words of wisdom on gout 4:58

  • First century AD: Gout is linked with excessive eating and drinking 6:01

  • Things get muddled 6:20

  • 1683: The modern era of gout is described 6:42

  • “Gout Perspectives” published in The Lancet in 2018 7:06

  • Self-taught Dutch scientist, Antony van Leeuwenhoek, pioneers the microscope and identifies tophi 8:29

  • Swedish chemist Carl Wilhelm Scheele discovers uric acid 11:38

  • William Hyde Wollaston tests tophi and discovers it’s full of uric acid 12:57

  • Emperor of uric acid, Alfred Baring Garrod, associates elevated serum uric acid with gout 13:48

  • If anyone knows how the thread test works, please email me 14:58

  • He theorized that uric acid causes gout 15:37

  • A look back at what we know 16:09

  • What we don’t know: What’s in the joints of patients with acute gout? 16:22

  • Stay tuned for The History of Gout, Part 2 16:34

We’d love to hear from you! Send your comments/questions to [email protected]).

References:

Barnett R. Lancet. 2018;391:2595.)

Faires JS, Mccarty DJ. Lancet. 1962;280:682-685.)  

Kippen I, et al. Ann Rheum Dis. 1974;33:391-396.)

Marson P, Pasero G. Reumatismo. 2011;63:199-206.)

Mccarty DJ, Hollander JL. Ann Intern Med. 1961;54:452-460.)

Nuki G, Simkin PA. Arthritis Res Ther. 2006;doi: 10.1186/ar1906.)

Rundles RW. Arch Intern Med. 1985;145:1492-1503.)

Shyambhavee, Behera BK. J Pharmacol Clin Toxicol. 2017;5:1098.)

Storey GD. Rheumatology. 2001;40:1189-1190.)

West JB. Am J Physiol Lung Cell Mol Physiol. 2014;doi:10.1152/ajplung.00223.2014.)