A Bovine Conundrum
Healio Rheuminations
Shownotes Transcript
This episode discusses the case of an 85-year-old man with a history of hypertension and fairly recently diagnosed bladder cancer who presents with oligoarticular asymmetric inflammatory arthritis. Explore the details of this case and learn how bacillus Calmette-Guérin and reactive arthritis are related in this diagnostic conundrum.
Intro :10
An 85-year-old man with a history of hypertension and recently diagnosed bladder cancer presents with oligoarticular asymmetric inflammatory arthritis :18
Details of his cancer history :32
How BCG (bacillus Calmette-Guérin) is used for superficial bladder cancer :53
Patient wakes with acute onset, rapidly progressing joint pain 1:21
Results of synovial aspiration of his right wrist 2:06
Physical exam findings and patient history 2:24
Discharged from outside hospital 2:53
Outpatient rheumatologist orders autoimmune serologies 3:03
Second hospital admission 3:24
Infectious disease evaluation 4:25
Patient presents to Cleveland Clinic 4:54
What do we have? 6:18
The main concern is he’s been instilled with bacteria 6:45
Could this be a reactive arthritis? 7:18
History of BCG 7:45
What do we know about what happens to these patients? 10:28
How do we define disseminated BCG infection vs. a reactive arthritis? 10:58
A single institution cohort of disseminated infection after BCG instillation 11:29
Comparing these definitions in our patient 14:34
A look at reactive arthritis 15:07
What do we use to treat these patients? 16:12
A look back at our patient 16:31
Continued treatment with triple therapy 17:05
A diagnostic conundrum 17:32
The diagnosis, in hindsight 18:11
Summary 18:49
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References:
Bernini L. Autoimmun Rev. 2013;12:1150-1159.)
Meyer J. Postgrad Med J. 2002;78:449-454.)
Pérez-Jacoiste Asín MA. Medicine (Baltimore). 2014;93:236-254.)
To U. Case Rep Med. 2014;doi:10.1155/2014/362845. )
